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- W2510166444 abstract "The fast-growing Mycobacterium smegmatis is generally used as a surrogate host to study the biology of its pathogenic counterpart, Mycobacterium tuberculosis. In particular, the use of M. smegmatis as a model system has significantly contributed to elucidate both physiological and molecular aspects of M. tuberculosis pathogenesis. Tuberculosis is considered a public health problem worldwide, killing around 1.4 million people each year. Mycobacterium tuberculosis infects human macrophages and actively replicates inside them. The host immune system mounts a strong response generating reactive oxygen and nitrogen species able to cause damage to DNA. Several studies revealed that M. tuberculosis is able to persist with such genotoxic compounds, safeguarding its genome integrity thanks to the combined action of several DNA repair pathways. Among them, the NER system seems to play a crucial role during infection. In silico analysis of mycobacterial genomes revealed that genes encoding enzymes required for the NER system are conserved among mycobacteria, with high sequence homology between M. tuberculosis and M. smegmatis genes. This chapter outlines the importance of mycobacterial DNA repair systems during infection, focusing on recent findings on the NER system in M. smegmatis." @default.
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- W2510166444 date "2016-08-12" @default.
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- W2510166444 title "Nucleotide Excision Repair System and Gene Expression inMycobacterium Smegmatis" @default.
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