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• W251017256 startingPage "1274" @default.
• W251017256 abstract "Objective: To review the mechanisms and clinical significance of adverse interactions between warfarin and nonsteroidal antiinflammatory drugs (NSAIDs) and discuss how these interactions can be avoided. Data Sources: Previous studies of interactions between warfarin and NSAIDs or reports of adverse interactions were identified from a MEDLINE search (1976 to present) and from the reference lists of pertinent articles. Study Selection And Data Extraction: All articles were considered for inclusion in the review. Pertinent information was selected for discussion. Data Synthesis: All NSAIDs can prolong bleeding time by inhibiting platelet function. High-dose aspirin has a direct hypoprothrombinemic effect. Phenylbutazone and its analogs enhance the hypoprothrombinemic effect of warfarin through a pharmacokinetic interaction by inhibiting the hepatic metabolism of warfarin. Mefenamic acid also enhances the anticoagulant effect of warfarin, but the mechanism is not known. The clinical relevance of protein binding displacement in the interaction between warfarin and NSAIDs has been overstated, although a significant one may be more likely in the presence of high concentrations of NSAIDs in patients with slow elimination of warfarin (e.g., those with severe heart failure or impaired liver function). NSAIDs can induce gastrointestinal bleeding, which is likely to be more severe if warfarin is also given. Conclusions: The combined use of warfarin and NSAIDs is generally discouraged because of the increased risk of bleeding in these patients. In patients receiving warfarin who also require NSAIDs, phenylbutazone and its analogs, high-dose aspirin, mefenamic acid, excessive use of topical methyl salicylate, and NSAIDs that are associated with a higher risk of bleeding peptic ulcers should be avoided. Patients should be closely monitored for anticoagulant control and bleeding complications during the combined use of warfarin and NSAIDs." @default.
• W251017256 created "2016-06-24" @default.
• W251017256 creator A5007046259 @default.
• W251017256 date "1995-12-01" @default.
• W251017256 modified "2023-09-29" @default.
• W251017256 title "Adverse Interactions Between Warfarin and Nonsteroidal Antiinflammatory Drugs: Mechanisms, Clinical Significance, and Avoidance" @default.
• W251017256 cites W163738715 @default.
• W251017256 cites W1966475703 @default.
• W251017256 cites W1973081920 @default.
• W251017256 cites W1973811753 @default.
• W251017256 cites W1978893964 @default.
• W251017256 cites W1983963462 @default.
• W251017256 cites W1985046233 @default.
• W251017256 cites W1987531347 @default.
• W251017256 cites W1989612908 @default.
• W251017256 cites W1989946528 @default.
• W251017256 cites W1993615487 @default.
• W251017256 cites W1994237400 @default.
• W251017256 cites W2000916342 @default.
• W251017256 cites W2002432842 @default.
• W251017256 cites W2005703781 @default.
• W251017256 cites W2007229610 @default.
• W251017256 cites W2007303097 @default.
• W251017256 cites W2012714913 @default.
• W251017256 cites W2014101233 @default.
• W251017256 cites W2017818343 @default.
• W251017256 cites W2018643028 @default.
• W251017256 cites W2018747988 @default.
• W251017256 cites W2026589095 @default.
• W251017256 cites W2026878380 @default.
• W251017256 cites W2031760606 @default.
• W251017256 cites W2033374178 @default.
• W251017256 cites W2038098872 @default.
• W251017256 cites W2038673826 @default.
• W251017256 cites W2042821840 @default.
• W251017256 cites W2043567141 @default.
• W251017256 cites W2047722602 @default.
• W251017256 cites W2048567767 @default.
• W251017256 cites W2051258491 @default.
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• W251017256 cites W2061482480 @default.
• W251017256 cites W2064543078 @default.
• W251017256 cites W2064836413 @default.
• W251017256 cites W2066490209 @default.
• W251017256 cites W2071472556 @default.
• W251017256 cites W2076023447 @default.
• W251017256 cites W2082716193 @default.
• W251017256 cites W2082895123 @default.
• W251017256 cites W2084678619 @default.
• W251017256 cites W2084760694 @default.
• W251017256 cites W2088135807 @default.
• W251017256 cites W2095333262 @default.
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• W251017256 cites W2110746182 @default.
• W251017256 cites W2128149368 @default.
• W251017256 cites W2137194730 @default.
• W251017256 cites W2140482107 @default.
• W251017256 cites W2143293555 @default.
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• W251017256 cites W2170602380 @default.
• W251017256 cites W2186442404 @default.
• W251017256 cites W2332721501 @default.
• W251017256 cites W2338244864 @default.
• W251017256 cites W2389419101 @default.
• W251017256 cites W2412899001 @default.
• W251017256 cites W2415235327 @default.
• W251017256 cites W2416245299 @default.
• W251017256 cites W2439750091 @default.
• W251017256 cites W2474479599 @default.
• W251017256 cites W2887057154 @default.
• W251017256 cites W2970076190 @default.
• W251017256 cites W3058535 @default.
• W251017256 cites W40811026 @default.
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• W251017256 doi "https://doi.org/10.1177/106002809502901214" @default.
• W251017256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8672833" @default.
• W251017256 hasPublicationYear "1995" @default.
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