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- W2510182002 abstract "Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood. Recent work has shown that nuclear pores, well known for their role in 3' processing and export of transcripts, also participate in the control of transcriptional initiation. We have recently begun to explore how nuclear pores interface with the well-described machinery that regulates initiation. This work led to the discovery that specific nucleoporins are required for binding of the repressor protein Mig1 to its site in target promoters. Nuclear pores are therefore involved in repressing, as well as activating, transcription. Here we discuss in detail the main models explaining our result and consider what each implies about the roles that nuclear pores play in the regulation of gene expression." @default.
- W2510182002 created "2016-09-16" @default.
- W2510182002 creator A5041948325 @default.
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- W2510182002 date "2012-01-01" @default.
- W2510182002 modified "2023-09-27" @default.
- W2510182002 title "Regulator of transcriptional repression and beyond" @default.
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