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- W2510183878 abstract "In order to improve the efficiency of the anti-inflammatory drug ibuprofen, cationic carbosilane dendrimers and dendrons with ibuprofen at their periphery or at their focal point, respectively, have been synthesized, and the release of the drug was studied using HPLC. Macrophages were used to evaluate the anti-inflammatory effect of the ibuprofen-conjugated dendritic systems and compared with mixtures of non-ibuprofen dendritic systems in the presence of the drug. The cationic ibuprofen-conjugated dendron was the compound that showed higher anti-inflammatory properties. It reduces the LPS-induced COX-2 expression and decreases the release of several inflammatory cytokines such as TNFα, IL-1β, IL-6, and CCL3. These results open new perspectives in the use of these compounds as drug carriers." @default.
- W2510183878 created "2016-09-16" @default.
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- W2510183878 date "2016-09-02" @default.
- W2510183878 modified "2023-10-15" @default.
- W2510183878 title "Improved Efficiency of Ibuprofen by Cationic Carbosilane Dendritic Conjugates" @default.
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- W2510183878 doi "https://doi.org/10.1021/acs.molpharmaceut.6b00420" @default.
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