FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510184211> ?p ?o ?g. }

• W2510184211 abstract "Complex diseases are often caused by the function of multiple genes, gene-gene (G×G) interactions as well as gene-environment (G×E) interactions. G×G and G×E interactions are ubiquitous in nature. Empirical evidences have shown that the effect of G×G interaction on disease risk could be largely modified by environmental changes. Such a G×G×E triple interaction could be a potential contributing factor to phenotypic plasticity. Although the role of environmental factors moderating genetic influences on disease risk has been broadly recognized, no statistical method has been developed to rigorously assess how environmental changes modify G×G interactions to affect disease risk. To address this issue, we developed a G×G×E triple interaction model in this work. We modeled the environmental modification effect via a varying-coefficient model where the structure of the varying effect is determined by data. Thus the model has the flexibility to assess nonlinear environmental moderation effect on G×G interaction. Simulation and real data analysis were conducted to show the utility of the method. Our approach provides a quantitative framework to assess triple interactions hypothesized in literature." @default.
• W2510184211 created "2016-09-16" @default.
• W2510184211 creator A5009613920 @default.
• W2510184211 creator A5042914019 @default.
• W2510184211 creator A5087339898 @default.
• W2510184211 date "2016-08-03" @default.
• W2510184211 modified "2023-09-25" @default.
• W2510184211 title "Statistical Identification of Gene-gene Interactions Triggered By Nonlinear Environmental Modulation" @default.
• W2510184211 cites W1966360257 @default.
• W2510184211 cites W1971231611 @default.
• W2510184211 cites W1971299565 @default.
• W2510184211 cites W1980991473 @default.
• W2510184211 cites W1998342470 @default.
• W2510184211 cites W2007362372 @default.
• W2510184211 cites W2028212562 @default.
• W2510184211 cites W2039684625 @default.
• W2510184211 cites W2060875624 @default.
• W2510184211 cites W2062329980 @default.
• W2510184211 cites W2063575312 @default.
• W2510184211 cites W2097508746 @default.
• W2510184211 cites W2110808585 @default.
• W2510184211 cites W2117175039 @default.
• W2510184211 cites W2118063646 @default.
• W2510184211 cites W2131878646 @default.
• W2510184211 cites W2136531343 @default.
• W2510184211 cites W2140162152 @default.
• W2510184211 cites W2144739046 @default.
• W2510184211 doi "https://doi.org/10.2174/1389202917666160726150417" @default.
• W2510184211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5320540" @default.
• W2510184211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28479867" @default.
• W2510184211 hasPublicationYear "2016" @default.
• W2510184211 type Work @default.
• W2510184211 sameAs 2510184211 @default.
• W2510184211 citedByCount "0" @default.
• W2510184211 crossrefType "journal-article" @default.
• W2510184211 hasAuthorship W2510184211A5009613920 @default.
• W2510184211 hasAuthorship W2510184211A5042914019 @default.
• W2510184211 hasAuthorship W2510184211A5087339898 @default.
• W2510184211 hasBestOaLocation W25101842112 @default.
• W2510184211 hasConcept C104317684 @default.
• W2510184211 hasConcept C105795698 @default.
• W2510184211 hasConcept C116834253 @default.
• W2510184211 hasConcept C119857082 @default.
• W2510184211 hasConcept C120936955 @default.
• W2510184211 hasConcept C121332964 @default.
• W2510184211 hasConcept C127716648 @default.
• W2510184211 hasConcept C130947863 @default.
• W2510184211 hasConcept C135763542 @default.
• W2510184211 hasConcept C14036430 @default.
• W2510184211 hasConcept C142724271 @default.
• W2510184211 hasConcept C15744967 @default.
• W2510184211 hasConcept C158622935 @default.
• W2510184211 hasConcept C18903297 @default.
• W2510184211 hasConcept C2776035688 @default.
• W2510184211 hasConcept C2779134260 @default.
• W2510184211 hasConcept C2780598303 @default.
• W2510184211 hasConcept C28662235 @default.
• W2510184211 hasConcept C33923547 @default.
• W2510184211 hasConcept C41008148 @default.
• W2510184211 hasConcept C46312422 @default.
• W2510184211 hasConcept C54355233 @default.
• W2510184211 hasConcept C62520636 @default.
• W2510184211 hasConcept C70721500 @default.
• W2510184211 hasConcept C71924100 @default.
• W2510184211 hasConcept C855514 @default.
• W2510184211 hasConcept C86803240 @default.
• W2510184211 hasConcept C93225998 @default.
• W2510184211 hasConceptScore W2510184211C104317684 @default.
• W2510184211 hasConceptScore W2510184211C105795698 @default.
• W2510184211 hasConceptScore W2510184211C116834253 @default.
• W2510184211 hasConceptScore W2510184211C119857082 @default.
• W2510184211 hasConceptScore W2510184211C120936955 @default.
• W2510184211 hasConceptScore W2510184211C121332964 @default.
• W2510184211 hasConceptScore W2510184211C127716648 @default.
• W2510184211 hasConceptScore W2510184211C130947863 @default.
• W2510184211 hasConceptScore W2510184211C135763542 @default.
• W2510184211 hasConceptScore W2510184211C14036430 @default.
• W2510184211 hasConceptScore W2510184211C142724271 @default.
• W2510184211 hasConceptScore W2510184211C15744967 @default.
• W2510184211 hasConceptScore W2510184211C158622935 @default.
• W2510184211 hasConceptScore W2510184211C18903297 @default.
• W2510184211 hasConceptScore W2510184211C2776035688 @default.
• W2510184211 hasConceptScore W2510184211C2779134260 @default.
• W2510184211 hasConceptScore W2510184211C2780598303 @default.
• W2510184211 hasConceptScore W2510184211C28662235 @default.
• W2510184211 hasConceptScore W2510184211C33923547 @default.
• W2510184211 hasConceptScore W2510184211C41008148 @default.
• W2510184211 hasConceptScore W2510184211C46312422 @default.
• W2510184211 hasConceptScore W2510184211C54355233 @default.
• W2510184211 hasConceptScore W2510184211C62520636 @default.
• W2510184211 hasConceptScore W2510184211C70721500 @default.
• W2510184211 hasConceptScore W2510184211C71924100 @default.
• W2510184211 hasConceptScore W2510184211C855514 @default.
• W2510184211 hasConceptScore W2510184211C86803240 @default.
• W2510184211 hasConceptScore W2510184211C93225998 @default.
• W2510184211 hasLocation W25101842111 @default.
• W2510184211 hasLocation W25101842112 @default.
• W2510184211 hasLocation W25101842113 @default.
• W2510184211 hasLocation W25101842114 @default.
• W2510184211 hasOpenAccess W2510184211 @default.

• next