Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510315903> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2510315903 endingPage "e460" @default.
- W2510315903 startingPage "e460" @default.
- W2510315903 abstract "Currently considered incurable, multiple myeloma (MM) is characterized by proliferation of malignant plasma cells (PC) predominantly in the bone marrow, which overproduce monoclonal immunoglobulin proteins, and a perturbed tumor microenvironment, which promotes PC survival, inhibits osteoblast activity, increases osteoclast activity, and leads to hallmark osteolytic bone disease, all of which contribute to the clinical manifestations of the disease. Disrupting these sequelae by incorporation of proteasome inhibitors and immunomodulatory drugs into treatment regimens has improved overall survival of MM patients; however, the majority of patients will become refractory to the most effective currently available therapeutic options and relapse.1 It is hypothesized that a drug-resistant population of myeloma stem cells promotes disease relapse, but the characteristics and identity of this cell type(s) remain uncertain.2 Expression of maternal embryonic leucine zipper kinase (MELK) is increased in a number of cancers and is associated with poorer prognosis. MELK activity modulates many cellular and biological processes, including proliferation, apoptosis, hematopoiesis and oncogenesis, and is believed to have a critical role in cancer stem cell maintenance.3" @default.
- W2510315903 created "2016-09-16" @default.
- W2510315903 creator A5016569283 @default.
- W2510315903 creator A5022169422 @default.
- W2510315903 creator A5028493927 @default.
- W2510315903 creator A5057282547 @default.
- W2510315903 creator A5079171795 @default.
- W2510315903 creator A5081319086 @default.
- W2510315903 creator A5088800372 @default.
- W2510315903 date "2016-08-19" @default.
- W2510315903 modified "2023-10-12" @default.
- W2510315903 title "Anti-myeloma activity of MELK inhibitor OTS167: effects on drug-resistant myeloma cells and putative myeloma stem cell replenishment of malignant plasma cells" @default.
- W2510315903 cites W150727265 @default.
- W2510315903 cites W1997001746 @default.
- W2510315903 cites W2011018672 @default.
- W2510315903 cites W2055134485 @default.
- W2510315903 cites W2097710494 @default.
- W2510315903 cites W2115279327 @default.
- W2510315903 cites W2121411022 @default.
- W2510315903 cites W2132084215 @default.
- W2510315903 cites W2142793991 @default.
- W2510315903 cites W2148614367 @default.
- W2510315903 cites W2150997370 @default.
- W2510315903 cites W2155165473 @default.
- W2510315903 cites W2157423336 @default.
- W2510315903 cites W2193545358 @default.
- W2510315903 cites W2327089920 @default.
- W2510315903 doi "https://doi.org/10.1038/bcj.2016.71" @default.
- W2510315903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5022182" @default.
- W2510315903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27540718" @default.
- W2510315903 hasPublicationYear "2016" @default.
- W2510315903 type Work @default.
- W2510315903 sameAs 2510315903 @default.
- W2510315903 citedByCount "13" @default.
- W2510315903 countsByYear W25103159032017 @default.
- W2510315903 countsByYear W25103159032018 @default.
- W2510315903 countsByYear W25103159032019 @default.
- W2510315903 countsByYear W25103159032020 @default.
- W2510315903 countsByYear W25103159032021 @default.
- W2510315903 countsByYear W25103159032023 @default.
- W2510315903 crossrefType "journal-article" @default.
- W2510315903 hasAuthorship W2510315903A5016569283 @default.
- W2510315903 hasAuthorship W2510315903A5022169422 @default.
- W2510315903 hasAuthorship W2510315903A5028493927 @default.
- W2510315903 hasAuthorship W2510315903A5057282547 @default.
- W2510315903 hasAuthorship W2510315903A5079171795 @default.
- W2510315903 hasAuthorship W2510315903A5081319086 @default.
- W2510315903 hasAuthorship W2510315903A5088800372 @default.
- W2510315903 hasBestOaLocation W25103159031 @default.
- W2510315903 hasConcept C126322002 @default.
- W2510315903 hasConcept C2776364478 @default.
- W2510315903 hasConcept C2776396001 @default.
- W2510315903 hasConcept C2780035454 @default.
- W2510315903 hasConcept C28328180 @default.
- W2510315903 hasConcept C2908937092 @default.
- W2510315903 hasConcept C502942594 @default.
- W2510315903 hasConcept C71924100 @default.
- W2510315903 hasConcept C86803240 @default.
- W2510315903 hasConcept C95444343 @default.
- W2510315903 hasConcept C98274493 @default.
- W2510315903 hasConceptScore W2510315903C126322002 @default.
- W2510315903 hasConceptScore W2510315903C2776364478 @default.
- W2510315903 hasConceptScore W2510315903C2776396001 @default.
- W2510315903 hasConceptScore W2510315903C2780035454 @default.
- W2510315903 hasConceptScore W2510315903C28328180 @default.
- W2510315903 hasConceptScore W2510315903C2908937092 @default.
- W2510315903 hasConceptScore W2510315903C502942594 @default.
- W2510315903 hasConceptScore W2510315903C71924100 @default.
- W2510315903 hasConceptScore W2510315903C86803240 @default.
- W2510315903 hasConceptScore W2510315903C95444343 @default.
- W2510315903 hasConceptScore W2510315903C98274493 @default.
- W2510315903 hasIssue "8" @default.
- W2510315903 hasLocation W25103159031 @default.
- W2510315903 hasLocation W25103159032 @default.
- W2510315903 hasLocation W25103159033 @default.
- W2510315903 hasLocation W25103159034 @default.
- W2510315903 hasOpenAccess W2510315903 @default.
- W2510315903 hasPrimaryLocation W25103159031 @default.
- W2510315903 hasRelatedWork W2005843898 @default.
- W2510315903 hasRelatedWork W2088316980 @default.
- W2510315903 hasRelatedWork W2218447560 @default.
- W2510315903 hasRelatedWork W2406089054 @default.
- W2510315903 hasRelatedWork W2893011256 @default.
- W2510315903 hasRelatedWork W2949617280 @default.
- W2510315903 hasRelatedWork W3168598779 @default.
- W2510315903 hasRelatedWork W4231880000 @default.
- W2510315903 hasRelatedWork W4256070036 @default.
- W2510315903 hasRelatedWork W4283034076 @default.
- W2510315903 hasVolume "6" @default.
- W2510315903 isParatext "false" @default.
- W2510315903 isRetracted "false" @default.
- W2510315903 magId "2510315903" @default.
- W2510315903 workType "article" @default.