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• W2510345386 endingPage "693" @default.
• W2510345386 startingPage "680" @default.
• W2510345386 abstract "The thalamus is the major source of cortical inputs shaping sensation, action, and cognition. Thalamic circuits are targeted by two major inhibitory systems: the thalamic reticular nucleus (TRN) and extrathalamic inhibitory (ETI) inputs. A unifying framework of how these systems operate is currently lacking. Here, we propose that TRN circuits are specialized to exert thalamic control at different spatiotemporal scales. Local inhibition of thalamic spike rates prevails during attentional selection, whereas global inhibition more likely prevails during sleep. In contrast, the ETI (arising from basal ganglia, zona incerta (ZI), anterior pretectum, and pontine reticular formation) provides temporally precise and focal inhibition, impacting spike timing. Together, these inhibitory systems allow graded control of thalamic output, enabling thalamocortical operations to dynamically match ongoing behavioral demands." @default.
• W2510345386 created "2016-09-16" @default.
• W2510345386 creator A5076929032 @default.
• W2510345386 creator A5084779684 @default.
• W2510345386 date "2016-10-01" @default.
• W2510345386 modified "2023-10-04" @default.
• W2510345386 title "Thalamic Inhibition: Diverse Sources, Diverse Scales" @default.
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