Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510360178> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2510360178 endingPage "130" @default.
- W2510360178 startingPage "126" @default.
- W2510360178 abstract "Human cytotoxic T-lymphocyte (CTL) lines with specificity restricted for autologous squamous cell carcinoma of the head and neck (SCCHN) were established from peripheral blood lymphocytes (PBL) obtained from a patient with cancer of the tongue. The CTL lines were CD3+CD8+CD11b-HLA-DR+T cell receptors (TCR) α /β+. They were tested in 4 h 51Cr-release assays against SCCHN cell lines (n=11) and a variety of non-squamous human tumors (n=9) and normal (n=5) cell targets. They were found to lyse only autologous rumor (AuTu, PCI-50) and seven allogeneic SCCHN cell lines. Of these tumor cell lines, three cell lines shared a HLA-A2 locus with the AuTu, while the other two lines shared HLA-B44 with AuTu. Lysis of AuTu and the allogeneic SCCHN targets of the established CTL lines appeared to be MHC-class I restricted. The CTL lines proliferated in vitro in response to autologous PCI-50 or an allogeneic SCCHN cell line. Analysis of the TCRβ chain genes for the CTL and CTL clones indicated that two different CTL populations (Vβ6 and Vβ2) are able to recognize SCCHN-associated antigen (s) and that Vβ6 T cells are HLA-A2-restricted, while Vβ2 T cells may be HLA-B44-restricted.While the growth of PCI-50 cells in culture was significantly inhibited by the supernatants of A-NK cells, those of the CTL line were not growth inhibitory. On the other hand, the lysis of AuTu targets by the CTL line was increased by preincubation of tumor cells with TNFα or IFNγ. These cytokines augmented the expression of HLA-class I, HLA-class II and intercellular adhesion molecule I (ICAM-I) on PCI-50 cells. The CTL incubated in the presence of HLA-A2 SCCHNs but not HLA-A2 gastric carcinoma produced TNFα, IFNγ and GMCSF." @default.
- W2510360178 created "2016-09-16" @default.
- W2510360178 creator A5080423219 @default.
- W2510360178 date "1995-01-01" @default.
- W2510360178 modified "2023-10-02" @default.
- W2510360178 title "Squamous Cell Carcinoma in the Region of Respiratory and Digestive Organs. Cellular and Molecular Analyses. A Human Cytotoxic T Cell Line with Restricted Specificity for Squamous Cell Carcinoma." @default.
- W2510360178 cites W1492624446 @default.
- W2510360178 cites W1577820717 @default.
- W2510360178 cites W1605818764 @default.
- W2510360178 cites W1651198898 @default.
- W2510360178 cites W1975985284 @default.
- W2510360178 cites W2130185552 @default.
- W2510360178 doi "https://doi.org/10.2468/jbes.46.126" @default.
- W2510360178 hasPublicationYear "1995" @default.
- W2510360178 type Work @default.
- W2510360178 sameAs 2510360178 @default.
- W2510360178 citedByCount "0" @default.
- W2510360178 crossrefType "journal-article" @default.
- W2510360178 hasAuthorship W2510360178A5080423219 @default.
- W2510360178 hasBestOaLocation W25103601781 @default.
- W2510360178 hasConcept C147483822 @default.
- W2510360178 hasConcept C147969180 @default.
- W2510360178 hasConcept C153911025 @default.
- W2510360178 hasConcept C154317977 @default.
- W2510360178 hasConcept C167672396 @default.
- W2510360178 hasConcept C202751555 @default.
- W2510360178 hasConcept C203014093 @default.
- W2510360178 hasConcept C2776090121 @default.
- W2510360178 hasConcept C502942594 @default.
- W2510360178 hasConcept C54355233 @default.
- W2510360178 hasConcept C71924100 @default.
- W2510360178 hasConcept C81885089 @default.
- W2510360178 hasConcept C86803240 @default.
- W2510360178 hasConcept C8891405 @default.
- W2510360178 hasConceptScore W2510360178C147483822 @default.
- W2510360178 hasConceptScore W2510360178C147969180 @default.
- W2510360178 hasConceptScore W2510360178C153911025 @default.
- W2510360178 hasConceptScore W2510360178C154317977 @default.
- W2510360178 hasConceptScore W2510360178C167672396 @default.
- W2510360178 hasConceptScore W2510360178C202751555 @default.
- W2510360178 hasConceptScore W2510360178C203014093 @default.
- W2510360178 hasConceptScore W2510360178C2776090121 @default.
- W2510360178 hasConceptScore W2510360178C502942594 @default.
- W2510360178 hasConceptScore W2510360178C54355233 @default.
- W2510360178 hasConceptScore W2510360178C71924100 @default.
- W2510360178 hasConceptScore W2510360178C81885089 @default.
- W2510360178 hasConceptScore W2510360178C86803240 @default.
- W2510360178 hasConceptScore W2510360178C8891405 @default.
- W2510360178 hasIssue "2" @default.
- W2510360178 hasLocation W25103601781 @default.
- W2510360178 hasOpenAccess W2510360178 @default.
- W2510360178 hasPrimaryLocation W25103601781 @default.
- W2510360178 hasRelatedWork W1605269473 @default.
- W2510360178 hasRelatedWork W1676011408 @default.
- W2510360178 hasRelatedWork W1965302438 @default.
- W2510360178 hasRelatedWork W1972548547 @default.
- W2510360178 hasRelatedWork W2011834818 @default.
- W2510360178 hasRelatedWork W2042249429 @default.
- W2510360178 hasRelatedWork W2050790509 @default.
- W2510360178 hasRelatedWork W2065598300 @default.
- W2510360178 hasRelatedWork W2075267526 @default.
- W2510360178 hasRelatedWork W2092186105 @default.
- W2510360178 hasRelatedWork W2151768520 @default.
- W2510360178 hasRelatedWork W2153194315 @default.
- W2510360178 hasRelatedWork W2185501589 @default.
- W2510360178 hasRelatedWork W2317626419 @default.
- W2510360178 hasRelatedWork W2320027406 @default.
- W2510360178 hasRelatedWork W2384593388 @default.
- W2510360178 hasRelatedWork W2465100742 @default.
- W2510360178 hasRelatedWork W2565107925 @default.
- W2510360178 hasRelatedWork W2587092565 @default.
- W2510360178 hasRelatedWork W2980303855 @default.
- W2510360178 hasVolume "46" @default.
- W2510360178 isParatext "false" @default.
- W2510360178 isRetracted "false" @default.
- W2510360178 magId "2510360178" @default.
- W2510360178 workType "article" @default.