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- W2510362766 endingPage "3707" @default.
- W2510362766 startingPage "3699" @default.
- W2510362766 abstract "HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably Il1b. The mechanism of LPS-stimulated HIF1α induction involves succinate, which inhibits prolyl hydroxylases (PHDs). Pyruvate kinase M2 (PKM2) is also induced and interacts with and promotes the function of HIF1α. In another critical inflammatory cell type, Th17 cells, HIF1α acts via the retinoic acid–related orphan receptor-γt (RORγt) to drive Th17 differentiation. HIF1α is therefore a key reprogrammer of metabolism in inflammatory cells that promotes inflammatory gene expression." @default.
- W2510362766 created "2016-09-16" @default.
- W2510362766 creator A5060285056 @default.
- W2510362766 creator A5065688806 @default.
- W2510362766 date "2016-08-29" @default.
- W2510362766 modified "2023-10-14" @default.
- W2510362766 title "HIF1α and metabolic reprogramming in inflammation" @default.
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