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• W2510363349 abstract "Intestinal microfold (M) cells are epithelial cells primarily present on Peyer's patches (PPs) in the small intestine. The ability of M cells to shuttle antigens into the PP for appropriate immune responses makes M cells a target for next-generation oral vaccine delivery. In this regard, discovery of M cell-specific receptors are of great interest, which could act as molecular tags for targeted delivery of cargo to M cells. Here, using a monoclonal antibody we generated to the Sialic acid-binding immunoglobulin-like lectin F (Siglec-F), we show that Siglec-F is expressed on mouse M cells in the small intestine. Immunohistochemical analysis of the PP tissue sections shows that Siglec-F is expressed on the surface of the M cell membrane exposed to the intestinal lumen. Anti-Siglec-F antibody injected into the mouse small intestine bound to M cells, demonstrating the potential to target M cells via Siglec-F." @default.
• W2510363349 created "2016-09-16" @default.
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• W2510363349 date "2016-10-01" @default.
• W2510363349 modified "2023-10-13" @default.
• W2510363349 title "Siglec-F is a novel intestinal M cell marker" @default.
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• W2510363349 doi "https://doi.org/10.1016/j.bbrc.2016.08.055" @default.
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