FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510456782> ?p ?o ?g. }

• W2510456782 endingPage "1417" @default.
• W2510456782 startingPage "1417" @default.
• W2510456782 abstract "Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb). Due to the extensive use of anti-tuberculosis drugs and the development of mutations, the emergence and spread of multidrug-resistant tuberculosis is recognized as one of the most dangerous threats to global tuberculosis control. Some single mutations have been identified to be significantly linked with drug resistance. However, the prior research did not take gene-gene interactions into account, and the emergence of transmissible drug resistance is connected with multiple genetic mutations. In this study we use the bioinformatics software GBOOST (The Hong Kong University, Clear Water Bay, Kowloon, Hong Kong, China) to calculate the interactions of Single Nucleotide Polymorphism (SNP) pairs and identify gene pairs associated with drug resistance. A large part of the non-synonymous mutations in the drug target genes that were included in the screened gene pairs were confirmed by previous reports, which lent sound solid credits to the effectiveness of our method. Notably, most of the identified gene pairs containing drug targets also comprise Pro-Pro-Glu (PPE) family proteins, suggesting that PPE family proteins play important roles in the drug resistance of Mtb. Therefore, this study provides deeper insights into the mechanisms underlying anti-tuberculosis drug resistance, and the present method is useful for exploring the drug resistance mechanisms for other microorganisms." @default.
• W2510456782 created "2016-09-16" @default.
• W2510456782 creator A5025275790 @default.
• W2510456782 creator A5029469104 @default.
• W2510456782 creator A5037292349 @default.
• W2510456782 creator A5058691896 @default.
• W2510456782 creator A5082796153 @default.
• W2510456782 date "2016-08-27" @default.
• W2510456782 modified "2023-09-24" @default.
• W2510456782 title "Bioinformatics Identification of Drug Resistance-Associated Gene Pairs in Mycobacterium tuberculosis" @default.
• W2510456782 cites W1496881415 @default.
• W2510456782 cites W1583996382 @default.
• W2510456782 cites W1919905351 @default.
• W2510456782 cites W1973027758 @default.
• W2510456782 cites W1974872801 @default.
• W2510456782 cites W2006128966 @default.
• W2510456782 cites W2023848862 @default.
• W2510456782 cites W2037980409 @default.
• W2510456782 cites W2049363067 @default.
• W2510456782 cites W2058441401 @default.
• W2510456782 cites W2061701821 @default.
• W2510456782 cites W2072244058 @default.
• W2510456782 cites W2075000963 @default.
• W2510456782 cites W2080546445 @default.
• W2510456782 cites W2082473988 @default.
• W2510456782 cites W2089421768 @default.
• W2510456782 cites W2095222153 @default.
• W2510456782 cites W2100219680 @default.
• W2510456782 cites W2104237442 @default.
• W2510456782 cites W2108234281 @default.
• W2510456782 cites W2117138514 @default.
• W2510456782 cites W2131271579 @default.
• W2510456782 cites W2135027892 @default.
• W2510456782 cites W2140586560 @default.
• W2510456782 cites W2144651829 @default.
• W2510456782 cites W2148922378 @default.
• W2510456782 cites W2155943701 @default.
• W2510456782 cites W2161633633 @default.
• W2510456782 cites W2162190374 @default.
• W2510456782 cites W2170377094 @default.
• W2510456782 cites W2170551349 @default.
• W2510456782 cites W2277656229 @default.
• W2510456782 cites W2306598644 @default.
• W2510456782 cites W2344040166 @default.
• W2510456782 cites W2418131970 @default.
• W2510456782 cites W2950232131 @default.
• W2510456782 doi "https://doi.org/10.3390/ijms17091417" @default.
• W2510456782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5037696" @default.
• W2510456782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27618895" @default.
• W2510456782 hasPublicationYear "2016" @default.
• W2510456782 type Work @default.
• W2510456782 sameAs 2510456782 @default.
• W2510456782 citedByCount "20" @default.
• W2510456782 countsByYear W25104567822017 @default.
• W2510456782 countsByYear W25104567822018 @default.
• W2510456782 countsByYear W25104567822019 @default.
• W2510456782 countsByYear W25104567822020 @default.
• W2510456782 countsByYear W25104567822021 @default.
• W2510456782 countsByYear W25104567822022 @default.
• W2510456782 countsByYear W25104567822023 @default.
• W2510456782 crossrefType "journal-article" @default.
• W2510456782 hasAuthorship W2510456782A5025275790 @default.
• W2510456782 hasAuthorship W2510456782A5029469104 @default.
• W2510456782 hasAuthorship W2510456782A5037292349 @default.
• W2510456782 hasAuthorship W2510456782A5058691896 @default.
• W2510456782 hasAuthorship W2510456782A5082796153 @default.
• W2510456782 hasBestOaLocation W25104567821 @default.
• W2510456782 hasConcept C104317684 @default.
• W2510456782 hasConcept C114851261 @default.
• W2510456782 hasConcept C133936738 @default.
• W2510456782 hasConcept C135763542 @default.
• W2510456782 hasConcept C139275648 @default.
• W2510456782 hasConcept C142724271 @default.
• W2510456782 hasConcept C153209595 @default.
• W2510456782 hasConcept C159047783 @default.
• W2510456782 hasConcept C2777975735 @default.
• W2510456782 hasConcept C2780035454 @default.
• W2510456782 hasConcept C2781069245 @default.
• W2510456782 hasConcept C54355233 @default.
• W2510456782 hasConcept C71924100 @default.
• W2510456782 hasConcept C86803240 @default.
• W2510456782 hasConcept C98274493 @default.
• W2510456782 hasConceptScore W2510456782C104317684 @default.
• W2510456782 hasConceptScore W2510456782C114851261 @default.
• W2510456782 hasConceptScore W2510456782C133936738 @default.
• W2510456782 hasConceptScore W2510456782C135763542 @default.
• W2510456782 hasConceptScore W2510456782C139275648 @default.
• W2510456782 hasConceptScore W2510456782C142724271 @default.
• W2510456782 hasConceptScore W2510456782C153209595 @default.
• W2510456782 hasConceptScore W2510456782C159047783 @default.
• W2510456782 hasConceptScore W2510456782C2777975735 @default.
• W2510456782 hasConceptScore W2510456782C2780035454 @default.
• W2510456782 hasConceptScore W2510456782C2781069245 @default.
• W2510456782 hasConceptScore W2510456782C54355233 @default.
• W2510456782 hasConceptScore W2510456782C71924100 @default.
• W2510456782 hasConceptScore W2510456782C86803240 @default.
• W2510456782 hasConceptScore W2510456782C98274493 @default.
• W2510456782 hasFunder F4320322186 @default.

• next