FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510485927> ?p ?o ?g. }

• W2510485927 endingPage "655" @default.
• W2510485927 startingPage "645" @default.
• W2510485927 abstract "The comparative effectiveness of two dosage forms of metoprolol, the 120mg slow release tablet (SR) administered once daily and the 40mg conventional tablet (CO) given three times daily, on premature ventricular contraction (PVC) and heart rate (HR) was examined in patients with PVC of≥3, 000 beats/24 hr by employing a Holter ECG with a 24-hour monitor using a cross-over design, and changes with time in plasma concentrations after administration of SR and CO were measured.The mean of the PVC values which were monitored three times in the observation period under placebo was 710±184 beats/hr (Mean±S. E.) and the diurnal variation of PVC was high, averaging 34.2±6.5%. In the treatment periods, five patients showed significant reduction of PVC values by more than 25% in comparison to the placebo treated period in one of the intervals, showing reduction values during the whole day, the daytime, and the night-time of 37.8±13.3%, 46.5±15.1%, and-91.7±103.3% under SR, respectively. The reduction rates under CO tended to be higher in comparison to SR, showing 52.6±12.3%, 59.7±11.0% and 24.5±15.0%, respectively. No significant difference was noted between SR and CO . The duration of inhibitory effect on PVC was about 12 hours under SR and about 17 hours under CO.In the treatment periods, HR under both SR and CO was inhibited significantly in comparison with that in the observation period . No significant difference in inhibition of HR was seen between SR and CO. The inhibition on HR under CO was slightly higher than that under SR during the interval from night to early morning . These inhibitions were maintained over 24 hours.The plasma concentrations after administration of SR and CO did not show any significant difference. The plasma concentration level which is considered to be sufficient to inhibit HR was maintained even at 24 hours after administration of SR, (11.3±7.8ng/ml).In conclusion, SR maintained the inhibitory effect on HR for 24 hours similarly to that under CO, but was thought to be inferior to CO in its inhibitory effect on PVC . This may be due to the difference in the threshold plasma concentrations to inhibit HR and PVC and the lower plasma concentrations during night-time in the SR treatment period." @default.
• W2510485927 created "2016-09-16" @default.
• W2510485927 creator A5010531715 @default.
• W2510485927 creator A5025390571 @default.
• W2510485927 creator A5038163394 @default.
• W2510485927 date "1986-01-01" @default.
• W2510485927 modified "2023-09-25" @default.
• W2510485927 title "Influence of single adiministration of metoprolol slow release (CF-15 SR) in patients with premature ventricular contractions : Comparison with metoprolol conventional tablet by cross-over study." @default.
• W2510485927 cites W1976398721 @default.
• W2510485927 cites W2001439330 @default.
• W2510485927 cites W2006272651 @default.
• W2510485927 cites W2015169899 @default.
• W2510485927 cites W2068019008 @default.
• W2510485927 doi "https://doi.org/10.3999/jscpt.17.645" @default.
• W2510485927 hasPublicationYear "1986" @default.
• W2510485927 type Work @default.
• W2510485927 sameAs 2510485927 @default.
• W2510485927 citedByCount "0" @default.
• W2510485927 crossrefType "journal-article" @default.
• W2510485927 hasAuthorship W2510485927A5010531715 @default.
• W2510485927 hasAuthorship W2510485927A5025390571 @default.
• W2510485927 hasAuthorship W2510485927A5038163394 @default.
• W2510485927 hasBestOaLocation W25104859271 @default.
• W2510485927 hasConcept C126322002 @default.
• W2510485927 hasConcept C140793950 @default.
• W2510485927 hasConcept C142724271 @default.
• W2510485927 hasConcept C164705383 @default.
• W2510485927 hasConcept C185592680 @default.
• W2510485927 hasConcept C204787440 @default.
• W2510485927 hasConcept C27081682 @default.
• W2510485927 hasConcept C2777953023 @default.
• W2510485927 hasConcept C2781280847 @default.
• W2510485927 hasConcept C3018023364 @default.
• W2510485927 hasConcept C42219234 @default.
• W2510485927 hasConcept C71924100 @default.
• W2510485927 hasConcept C84393581 @default.
• W2510485927 hasConcept C86803240 @default.
• W2510485927 hasConceptScore W2510485927C126322002 @default.
• W2510485927 hasConceptScore W2510485927C140793950 @default.
• W2510485927 hasConceptScore W2510485927C142724271 @default.
• W2510485927 hasConceptScore W2510485927C164705383 @default.
• W2510485927 hasConceptScore W2510485927C185592680 @default.
• W2510485927 hasConceptScore W2510485927C204787440 @default.
• W2510485927 hasConceptScore W2510485927C27081682 @default.
• W2510485927 hasConceptScore W2510485927C2777953023 @default.
• W2510485927 hasConceptScore W2510485927C2781280847 @default.
• W2510485927 hasConceptScore W2510485927C3018023364 @default.
• W2510485927 hasConceptScore W2510485927C42219234 @default.
• W2510485927 hasConceptScore W2510485927C71924100 @default.
• W2510485927 hasConceptScore W2510485927C84393581 @default.
• W2510485927 hasConceptScore W2510485927C86803240 @default.
• W2510485927 hasIssue "4" @default.
• W2510485927 hasLocation W25104859271 @default.
• W2510485927 hasOpenAccess W2510485927 @default.
• W2510485927 hasPrimaryLocation W25104859271 @default.
• W2510485927 hasRelatedWork W1439487150 @default.
• W2510485927 hasRelatedWork W1952357885 @default.
• W2510485927 hasRelatedWork W1970552917 @default.
• W2510485927 hasRelatedWork W2024204748 @default.
• W2510485927 hasRelatedWork W2033978084 @default.
• W2510485927 hasRelatedWork W2040375523 @default.
• W2510485927 hasRelatedWork W2045313839 @default.
• W2510485927 hasRelatedWork W2047034515 @default.
• W2510485927 hasRelatedWork W2048462197 @default.
• W2510485927 hasRelatedWork W2057790387 @default.
• W2510485927 hasRelatedWork W2079174711 @default.
• W2510485927 hasRelatedWork W2095616064 @default.
• W2510485927 hasRelatedWork W2115213890 @default.
• W2510485927 hasRelatedWork W2268415451 @default.
• W2510485927 hasRelatedWork W2352065609 @default.
• W2510485927 hasRelatedWork W2397450623 @default.
• W2510485927 hasRelatedWork W2398662302 @default.
• W2510485927 hasRelatedWork W2469324211 @default.
• W2510485927 hasRelatedWork W262393329 @default.
• W2510485927 hasRelatedWork W107208054 @default.
• W2510485927 hasVolume "17" @default.
• W2510485927 isParatext "false" @default.
• W2510485927 isRetracted "false" @default.
• W2510485927 magId "2510485927" @default.
• W2510485927 workType "article" @default.