FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510486548> ?p ?o ?g. }

• W2510486548 abstract "Abstract Differentiation of the male and female gametes involves extremely well-regulated epigenetic and chromatin changes. An appropriate complement of the imprinted genes in the male and female gametes is essential to allow appropriate epigenetic regulation and development of the embryo. Therefore any perturbations of imprinting during the reproductive process have the potential to result in male or female infertility and/or subsequent anomalies. Epidemiological data in the human population and studies in animal models suggest that environmental exposures and diet may result in epigenetic changes, which may be linked to common multifactorial disorders and infertility. An abnormal pattern of sperm DNA methylation, sperm RNA content, and sperm chromatin gene poising has been reported in some infertile men. Also altered epigenetics is being detected in female reproductive anomalies such as polycystic ovary syndrome, endometriosis, and placental syndromes. Fortunately, reproductive dysfunction can be efficiently treated using assisted reproduction techniques. However, there are currently some concerns about whether the potential epigenetic immaturity of the gametes and the in vitro conditions used might result in epigenetic anomalies. While the vast majority of assisted reproduction children seem to be healthy, a slightly higher incidence of infants born with minor or major phenotypic or metabolic disturbances, or with known epigenetic syndromes such as Beckwith–Widemann, is under study. This chapter reviews the physiological epigenetic changes during reproduction and development, describes the main alterations associated with infertility or offspring defects potentially linked to epigenetics, and outlines the research frontiers currently being explored." @default.
• W2510486548 created "2016-09-16" @default.
• W2510486548 creator A5032707232 @default.
• W2510486548 date "2016-01-01" @default.
• W2510486548 modified "2023-09-24" @default.
• W2510486548 title "Reproductive Disease Epigenetics" @default.
• W2510486548 cites W110481942 @default.
• W2510486548 cites W1190019795 @default.
• W2510486548 cites W1412161755 @default.
• W2510486548 cites W1485856951 @default.
• W2510486548 cites W1488234983 @default.
• W2510486548 cites W1587143425 @default.
• W2510486548 cites W1685873630 @default.
• W2510486548 cites W1770521942 @default.
• W2510486548 cites W1817858605 @default.
• W2510486548 cites W1821797507 @default.
• W2510486548 cites W1873502896 @default.
• W2510486548 cites W1880912735 @default.
• W2510486548 cites W1923981005 @default.
• W2510486548 cites W1944955452 @default.
• W2510486548 cites W1967841068 @default.
• W2510486548 cites W1977274434 @default.
• W2510486548 cites W1978006592 @default.
• W2510486548 cites W1978386737 @default.
• W2510486548 cites W1978807208 @default.
• W2510486548 cites W1979335344 @default.
• W2510486548 cites W1987272410 @default.
• W2510486548 cites W1988643971 @default.
• W2510486548 cites W1989628613 @default.
• W2510486548 cites W1992188147 @default.
• W2510486548 cites W1992541066 @default.
• W2510486548 cites W1996617870 @default.
• W2510486548 cites W1997665714 @default.
• W2510486548 cites W2003764818 @default.
• W2510486548 cites W2005902510 @default.
• W2510486548 cites W2006814858 @default.
• W2510486548 cites W2012551759 @default.
• W2510486548 cites W2013017387 @default.
• W2510486548 cites W2014144126 @default.
• W2510486548 cites W2018304908 @default.
• W2510486548 cites W2018531315 @default.
• W2510486548 cites W2018602434 @default.
• W2510486548 cites W2025613570 @default.
• W2510486548 cites W2027272672 @default.
• W2510486548 cites W2034417921 @default.
• W2510486548 cites W2034669369 @default.
• W2510486548 cites W2034982332 @default.
• W2510486548 cites W2035074912 @default.
• W2510486548 cites W2035118720 @default.
• W2510486548 cites W2035143183 @default.
• W2510486548 cites W2037818631 @default.
• W2510486548 cites W2039000168 @default.
• W2510486548 cites W2042159956 @default.
• W2510486548 cites W2044282102 @default.
• W2510486548 cites W2046812684 @default.
• W2510486548 cites W2047469234 @default.
• W2510486548 cites W2050592293 @default.
• W2510486548 cites W2051076163 @default.
• W2510486548 cites W2057359773 @default.
• W2510486548 cites W2057470220 @default.
• W2510486548 cites W2057477277 @default.
• W2510486548 cites W2057937016 @default.
• W2510486548 cites W2059145054 @default.
• W2510486548 cites W2062913655 @default.
• W2510486548 cites W2068932012 @default.
• W2510486548 cites W2079955972 @default.
• W2510486548 cites W2080360745 @default.
• W2510486548 cites W2081518434 @default.
• W2510486548 cites W2082444663 @default.
• W2510486548 cites W2084601112 @default.
• W2510486548 cites W2085933036 @default.
• W2510486548 cites W2087199631 @default.
• W2510486548 cites W2091385966 @default.
• W2510486548 cites W2093024907 @default.
• W2510486548 cites W2095175852 @default.
• W2510486548 cites W2096391240 @default.
• W2510486548 cites W2097814975 @default.
• W2510486548 cites W2098439455 @default.
• W2510486548 cites W2098641745 @default.
• W2510486548 cites W2098711385 @default.
• W2510486548 cites W2099343472 @default.
• W2510486548 cites W2099721980 @default.
• W2510486548 cites W2102133685 @default.
• W2510486548 cites W2103163808 @default.
• W2510486548 cites W2103410123 @default.
• W2510486548 cites W2106423392 @default.
• W2510486548 cites W2106839771 @default.
• W2510486548 cites W2106843839 @default.
• W2510486548 cites W2107882638 @default.
• W2510486548 cites W2108160091 @default.
• W2510486548 cites W2112227475 @default.
• W2510486548 cites W2112484452 @default.
• W2510486548 cites W2113519163 @default.
• W2510486548 cites W2114673109 @default.
• W2510486548 cites W2115199535 @default.
• W2510486548 cites W2116046187 @default.
• W2510486548 cites W2117490877 @default.
• W2510486548 cites W2118017182 @default.
• W2510486548 cites W2118676910 @default.
• W2510486548 cites W2120200106 @default.

• next