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- W2510489363 abstract "Background & Objectives: Dexmedetomidine (DEX) is a highly selective alpha2-adrenoceptor agonist with sedative and analgesic properties which is also used in paediatric anesthesia. Although the pharmacokinetics of DEX has been studied in paediatric patients (1), there are no data for Chinese children available. The aim of this study was to characterize the pharmacokinetics of DEX in a Chinese paediatric population. Materials & Methods: After approval by the local clinical ethics committee and written informed consent from the parents, 39 Chinese children aged 1 to 9 yrs. undergoing surgery were enrolled in the study. DEX was administered as short infusion of 1 - 2 µg/kg in 10 min. Venous blood samples were drawn until 480 min after stop of infusion. DEX plasma concentrations were measured with HPLC and mass-spectrometry. Pharmacokinetic modelling was performed by population analysis using linear compartment models. Results: Data of 36 patients (age: 1-9 yrs, weight: 10-27 kg) were analyzed. The pharmacokinetics of DEX was best described by a two-compartment model with an allometric power model for body weight scaling: CL1,2=CL1,2 TV*(BW/70)0.75 and V1,2=V1,2 TV*(BW/70). The population estimates (95% CI) per 70 kg bodyweight were: elimination clearance CL1TV=36.2 (33.3 – 41.1) L/h, central volume of distribution V1TV=84.3 (70.3 – 91.4) L, intercompartmental clearance CL2TV=82.8 (63.6 – 136.6) L/h, peripheral volume of distribution V2TV=114 (95 - 149) L, and terminal half-life T1/2el=4.4 (3.6 – 5.3) h. Age did not show any influence on weight adjusted parameters. Conclusion: Chinese children showed a similar clearance but larger volumes of distribution and a longer terminal half-life when compared to previous studies of DEX in Caucasian children (1). References: 1. Potts et al. Pediatr Anesth 2009; 19: 1119-1129. Disclosure of Interest: None declared" @default.
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- W2510489363 date "2016-09-01" @default.
- W2510489363 modified "2023-09-25" @default.
- W2510489363 title "Abstract PR439" @default.
- W2510489363 doi "https://doi.org/10.1213/01.ane.0000492827.42876.5c" @default.
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