Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510780015> ?p ?o ?g. }
- W2510780015 endingPage "1256" @default.
- W2510780015 startingPage "1239" @default.
- W2510780015 abstract "Recent studies have shown substantial interplay between the apoptosis and necroptosis pathways. Necroptosis, a form of programmed cell death, has been found to stimulate the immune system contributing to the pathophysiology of several inflammation-mediated disorders. Determining the contribution of necroptotic signaling pathways to inflammation may lead to the development of selective and specific molecular target implicated necroptosis inhibitors. Areas covered: This review summarizes the recently published and patented necroptosis inhibitors as therapeutic targets in inflammation-mediated disorders. The role of several necroptosis inhibitors, focusing on specific signaling molecules, was discussed with particular attention to inflammation-mediated disorders. Data was obtained from Espacenet®, WIPO®, USPTO® patent websites, and other relevant sources (2006-2016). Expert opinion: Necroptosis inhibitors hold promise for treatment of inflammation-mediated clinical conditions in which necroptotic cell death plays a major role. Although necroptosis inhibitors reviewed in this survey showed inhibitory effects against several inflammation-mediated disorders, only a few have passed to the stage of clinical testing and need extensive research for therapeutic practice. Revisiting the existing drugs and developing novel necroptosis inhibiting agents as well as understanding their mechanism are essential. A detailed study of necroptosis function in animal models of inflammation may provide us an alternative strategy for the development of drug-like necroptosis inhibitors." @default.
- W2510780015 created "2016-09-16" @default.
- W2510780015 creator A5012291010 @default.
- W2510780015 creator A5027408617 @default.
- W2510780015 creator A5048644174 @default.
- W2510780015 date "2016-09-08" @default.
- W2510780015 modified "2023-10-18" @default.
- W2510780015 title "Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents" @default.
- W2510780015 cites W1523845694 @default.
- W2510780015 cites W1619424850 @default.
- W2510780015 cites W1832527043 @default.
- W2510780015 cites W1941543403 @default.
- W2510780015 cites W1965016180 @default.
- W2510780015 cites W1968023901 @default.
- W2510780015 cites W1969323641 @default.
- W2510780015 cites W1970461630 @default.
- W2510780015 cites W1971432612 @default.
- W2510780015 cites W1975312378 @default.
- W2510780015 cites W1975667190 @default.
- W2510780015 cites W1976881265 @default.
- W2510780015 cites W1976984647 @default.
- W2510780015 cites W1979032223 @default.
- W2510780015 cites W1983078635 @default.
- W2510780015 cites W1985057198 @default.
- W2510780015 cites W1985831101 @default.
- W2510780015 cites W1986581020 @default.
- W2510780015 cites W1988848002 @default.
- W2510780015 cites W1991997670 @default.
- W2510780015 cites W1993506009 @default.
- W2510780015 cites W1995217653 @default.
- W2510780015 cites W1995708251 @default.
- W2510780015 cites W2000501568 @default.
- W2510780015 cites W2001656004 @default.
- W2510780015 cites W2003796946 @default.
- W2510780015 cites W2005408613 @default.
- W2510780015 cites W2005928313 @default.
- W2510780015 cites W2007303185 @default.
- W2510780015 cites W2007827117 @default.
- W2510780015 cites W2008258524 @default.
- W2510780015 cites W2010354804 @default.
- W2510780015 cites W2010766264 @default.
- W2510780015 cites W2012985988 @default.
- W2510780015 cites W2013934583 @default.
- W2510780015 cites W2016902863 @default.
- W2510780015 cites W2019144360 @default.
- W2510780015 cites W2019761195 @default.
- W2510780015 cites W2022543185 @default.
- W2510780015 cites W2023931275 @default.
- W2510780015 cites W2026461109 @default.
- W2510780015 cites W2030194678 @default.
- W2510780015 cites W2031770492 @default.
- W2510780015 cites W2032331465 @default.
- W2510780015 cites W2033968700 @default.
- W2510780015 cites W2035774060 @default.
- W2510780015 cites W2038401000 @default.
- W2510780015 cites W2042985720 @default.
- W2510780015 cites W2044097582 @default.
- W2510780015 cites W2044600859 @default.
- W2510780015 cites W2048053987 @default.
- W2510780015 cites W2052605153 @default.
- W2510780015 cites W2052887239 @default.
- W2510780015 cites W2055063967 @default.
- W2510780015 cites W2056641170 @default.
- W2510780015 cites W2058824573 @default.
- W2510780015 cites W2058974513 @default.
- W2510780015 cites W2059738518 @default.
- W2510780015 cites W2060204808 @default.
- W2510780015 cites W2062110054 @default.
- W2510780015 cites W2063251795 @default.
- W2510780015 cites W2068508591 @default.
- W2510780015 cites W2070014208 @default.
- W2510780015 cites W2074154917 @default.
- W2510780015 cites W2077071204 @default.
- W2510780015 cites W2077479785 @default.
- W2510780015 cites W2078734483 @default.
- W2510780015 cites W2081113298 @default.
- W2510780015 cites W2083375860 @default.
- W2510780015 cites W2085794015 @default.
- W2510780015 cites W2086151723 @default.
- W2510780015 cites W2086665516 @default.
- W2510780015 cites W2087232320 @default.
- W2510780015 cites W2087790613 @default.
- W2510780015 cites W2089275663 @default.
- W2510780015 cites W2090263751 @default.
- W2510780015 cites W2090412310 @default.
- W2510780015 cites W2091263717 @default.
- W2510780015 cites W2096259698 @default.
- W2510780015 cites W2096923099 @default.
- W2510780015 cites W2099440890 @default.
- W2510780015 cites W2099626067 @default.
- W2510780015 cites W2099784932 @default.
- W2510780015 cites W2103515366 @default.
- W2510780015 cites W2104205504 @default.
- W2510780015 cites W2104694028 @default.
- W2510780015 cites W2107411016 @default.
- W2510780015 cites W2110648386 @default.
- W2510780015 cites W2110796758 @default.
- W2510780015 cites W2110865978 @default.