FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2510942012> ?p ?o ?g. }

• W2510942012 endingPage "e0162148" @default.
• W2510942012 startingPage "e0162148" @default.
• W2510942012 abstract "The Bacille Calmette Guérin (BCG) vaccine is the only routine vaccination at birth that effectively induces neonatal T-helper 1 (Th1)-polarized immune responses. The primary cytokine that drives CD4+ T-cell Th1 differentiation is interleukin (IL)-12 p70, a heterodimeric cytokine composed of the IL-12 p35 and IL-12 p40 subunits. We therefore examined the mechanisms involved in BCG vaccine stimulation of IL-12 p35 and p40 production from human umbilical cord (neonatal) cells. We found that BCG bacilli did not upregulate IL-12 p35 mRNA production, but upregulated IL-12 p40 mRNA production in a Toll-like receptor (TLR)2-dependent manner, in human neonatal monocyte-derived dendritic cells (mdDCs). The combination of TLR2 signaling, Type I interferon (IFN), and Type II IFN induced maximal levels of IL-12 p35 and p40 mRNA production in human neonatal mdDCs. The cell-free supernatants of reconstituted BCG vaccine vials contained extracellular mycobacterial (BCG) DNA which could induce IFN-α (Type I IFN) production in human neonatal plasmacytoid dendritic cells (pDCs). BCG bacilli also stimulated human neonatal CD16lo natural killer (NK) cells to produce IFN-γ (Type II IFN) in a TLR2-dependent manner. We have therefore proposed a model where BCG vaccine could stimulate the combination of neonatal conventional DCs (cDCs), pDCs, and CD16lo NK cells to produce optimal neonatal IL-12 p35 and p40 (IL-12 p70) production and subsequent CD4+ T-cell Th1 polarization. An adjuvant that emulates the mechanism by which the BCG vaccine stimulates neonatal IL-12 p35 and p40 production could improve vaccine strategies at birth for protection against intracellular pathogens and toxins." @default.
• W2510942012 created "2016-09-16" @default.
• W2510942012 creator A5018578104 @default.
• W2510942012 creator A5085396934 @default.
• W2510942012 date "2016-08-29" @default.
• W2510942012 modified "2023-10-18" @default.
• W2510942012 title "A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates" @default.
• W2510942012 cites W1525833221 @default.
• W2510942012 cites W1546142467 @default.
• W2510942012 cites W1578914995 @default.
• W2510942012 cites W1588790881 @default.
• W2510942012 cites W1677810254 @default.
• W2510942012 cites W1792374007 @default.
• W2510942012 cites W1969991674 @default.
• W2510942012 cites W1972941257 @default.
• W2510942012 cites W1995744610 @default.
• W2510942012 cites W1996699644 @default.
• W2510942012 cites W2002855771 @default.
• W2510942012 cites W2003964035 @default.
• W2510942012 cites W2005445722 @default.
• W2510942012 cites W2008935360 @default.
• W2510942012 cites W2011197389 @default.
• W2510942012 cites W2021495067 @default.
• W2510942012 cites W2062105897 @default.
• W2510942012 cites W2062835892 @default.
• W2510942012 cites W2067539471 @default.
• W2510942012 cites W2082649398 @default.
• W2510942012 cites W2090477263 @default.
• W2510942012 cites W2093683696 @default.
• W2510942012 cites W2102268409 @default.
• W2510942012 cites W2103753861 @default.
• W2510942012 cites W2105539666 @default.
• W2510942012 cites W2110594682 @default.
• W2510942012 cites W2112439253 @default.
• W2510942012 cites W2117053011 @default.
• W2510942012 cites W2126245681 @default.
• W2510942012 cites W2132666683 @default.
• W2510942012 cites W2139150306 @default.
• W2510942012 cites W2139731518 @default.
• W2510942012 cites W2145078103 @default.
• W2510942012 cites W2146839864 @default.
• W2510942012 cites W2149605803 @default.
• W2510942012 cites W2157533715 @default.
• W2510942012 cites W2170698511 @default.
• W2510942012 cites W2276328619 @default.
• W2510942012 cites W2283319013 @default.
• W2510942012 cites W2318256697 @default.
• W2510942012 cites W2345654247 @default.
• W2510942012 cites W62156454 @default.
• W2510942012 doi "https://doi.org/10.1371/journal.pone.0162148" @default.
• W2510942012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5003384" @default.
• W2510942012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27571272" @default.
• W2510942012 hasPublicationYear "2016" @default.
• W2510942012 type Work @default.
• W2510942012 sameAs 2510942012 @default.
• W2510942012 citedByCount "13" @default.
• W2510942012 countsByYear W25109420122017 @default.
• W2510942012 countsByYear W25109420122018 @default.
• W2510942012 countsByYear W25109420122019 @default.
• W2510942012 countsByYear W25109420122020 @default.
• W2510942012 countsByYear W25109420122021 @default.
• W2510942012 countsByYear W25109420122023 @default.
• W2510942012 crossrefType "journal-article" @default.
• W2510942012 hasAuthorship W2510942012A5018578104 @default.
• W2510942012 hasAuthorship W2510942012A5085396934 @default.
• W2510942012 hasBestOaLocation W25109420121 @default.
• W2510942012 hasConcept C136449434 @default.
• W2510942012 hasConcept C149532602 @default.
• W2510942012 hasConcept C154317977 @default.
• W2510942012 hasConcept C202751555 @default.
• W2510942012 hasConcept C203014093 @default.
• W2510942012 hasConcept C2778170410 @default.
• W2510942012 hasConcept C2778690821 @default.
• W2510942012 hasConcept C2781236682 @default.
• W2510942012 hasConcept C55493867 @default.
• W2510942012 hasConcept C86803240 @default.
• W2510942012 hasConcept C8891405 @default.
• W2510942012 hasConceptScore W2510942012C136449434 @default.
• W2510942012 hasConceptScore W2510942012C149532602 @default.
• W2510942012 hasConceptScore W2510942012C154317977 @default.
• W2510942012 hasConceptScore W2510942012C202751555 @default.
• W2510942012 hasConceptScore W2510942012C203014093 @default.
• W2510942012 hasConceptScore W2510942012C2778170410 @default.
• W2510942012 hasConceptScore W2510942012C2778690821 @default.
• W2510942012 hasConceptScore W2510942012C2781236682 @default.
• W2510942012 hasConceptScore W2510942012C55493867 @default.
• W2510942012 hasConceptScore W2510942012C86803240 @default.
• W2510942012 hasConceptScore W2510942012C8891405 @default.
• W2510942012 hasFunder F4320337355 @default.
• W2510942012 hasIssue "8" @default.
• W2510942012 hasLocation W25109420121 @default.
• W2510942012 hasLocation W25109420122 @default.
• W2510942012 hasLocation W25109420123 @default.
• W2510942012 hasLocation W25109420124 @default.
• W2510942012 hasLocation W25109420125 @default.
• W2510942012 hasLocation W25109420126 @default.
• W2510942012 hasLocation W25109420127 @default.
• W2510942012 hasOpenAccess W2510942012 @default.

• next