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• W2510978127 abstract "Event Abstract Back to Event The non-canonical effects of N-acetyl-d-glucosamine kinase on the formation of neuronal dendrites and axons M A. Islam1 and Il Soo Moon1* 1 Dongguk University Graduate School of Medicine, Department of Anatomy, Republic of Korea Previously, we reported that N-acetylglucosamine kinase (NAGK) plays an enzyme activity-independent, non-canonical role in the dendritogenesis of hippocampal neurons in culture. To elucidate the molecular mechanism, we conducted yeast two-hybrid screening to search for NAGK-binding proteins and found a specific interaction between NAGK and dynein light-chain roadblock type 1 (DYNLRB1). A proximity ligation assay (PLA) of NAGK-dynein followed by tubulin ICC showed the localization of PLA signals on microtubule fibers at dendritic branch points. NAGK-dynein PLA combined with Golgi ICC showed the colocalization of PLA signals with somal Golgi facing the apical dendrite and with Golgi outposts in dendritic branch points and distensions. NAGK-Golgi PLA followed by tubulin or DYNLRB1 ICC showed that PLA signals colocalized with DYNLRB1 at dendritic branch points and at somal Golgi, indicating a tripartite interaction between NAGK, dynein and Golgi. Finally, the ectopic introduction of a small peptide derived from the C-terminal amino acids 74-96 of DYNLRB1 resulted in the stunting of hippocampal dendrites in culture. Our data indicate that the NAGK-dynein-Golgi tripartite interaction at dendritic branch points functions to regulate dendritic growth and/or branching. Other non-canonical functions of NAGK in cell division and migration will also be presented. Keywords: Cell Division, Hippocampus, cell migration, Neuron, in vitro Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Free Paper Session 2: Molecular Mechanisms of the Nervous System Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Islam MA and Moon I (2016). The non-canonical effects of N-acetyl-d-glucosamine kinase on the formation of neuronal dendrites and axons. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00106 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Il Soo Moon, Dongguk University Graduate School of Medicine, Department of Anatomy, Gyeongju, Republic of Korea, moonis@dongguk.ac.kr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers M A Islam Il Soo Moon Google M A Islam Il Soo Moon Google Scholar M A Islam Il Soo Moon PubMed M A Islam Il Soo Moon Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2510978127 title "The non-canonical effects of N-acetyl-d-glucosamine kinase on the formation of neuronal dendrites and axons" @default.
• W2510978127 doi "https://doi.org/10.3389/conf.fncel.2016.36.00106" @default.
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