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- W2511116829 abstract "The Ca2+-dependent cell-cell adhesion sys- tem (CDS) is thought to be essential for the formation and maintenance of cell adhesion in a wide variety of tissues. Previ- ous studies suggested that CDS has some cell-type specificity; for example, the monoclonal antibody ECCD-1 selectively rec- ognizes CDS of certain epithelial tissues in mouse embryos but not nervous tissues. In the present study, we have obtained a monoclonal antibody, designated NCD-1, that disrupts con- nections between brain cells of mouse embryos. A series of ex- periments suggested that NCD-1 specifically recognizes CDS. We then determined the distribution of the NCD-1 antigen in various mouse tissues. NCD-1 reacted with cells of the follow- ing tissues and cell lines: nervous tissues from various sources, lens, striated muscle, cardiac muscle, glioma G26-20, adreno- cortical tumor Yl, and melanoma B16. None of these cells re- acted with ECCD-1, and the cells reactive with ECCD-1 did not react with NCD-1. There was also a class of cells that did not react with either ECCD-1 or NCD-1. These results suggest that cells in the body can be classified into at least three groups containing CDS of differing specificities. A map of the tissue localization of these different classes of CDS also suggests that the expression of cell-type-specific cell adhesion molecules in each tissue plays a crucial role in adhesion between the same cell types and segregation of different cell types in processes essential for animal morphogenesis." @default.
- W2511116829 created "2016-09-16" @default.
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- W2511116829 date "2016-01-01" @default.
- W2511116829 modified "2023-09-23" @default.
- W2511116829 title "A monoclonal antibody disrupting ( adhesion of brain tissues: Possible in animal pattern formation (adhesive specificity/tissue segregation/animal morphogenesis)" @default.
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