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- W2511177073 abstract "Madangamines are a group of bioactive marine sponge alkaloids, embodying an unprecedented diazapentacyclic skeletal type. The enantioselective total synthesis of madangamine D has been accomplished, and represents the first total synthesis of an alkaloid of the madangamine group. It involves the stereoselective construction of the diazatricyclic ABC core using a phenylglycinol-derived lactam as the starting enantiomeric scaffold and the subsequent assembly of the peripheral macrocyclic rings. The synthesis provides, for the first time, a pure sample of madangamine D and confirms the absolute configuration of this alkaloid family." @default.
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- W2511177073 date "2014-05-02" @default.
- W2511177073 modified "2023-10-17" @default.
- W2511177073 title "Total Synthesis of (+)-Madangamine D" @default.
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- W2511177073 doi "https://doi.org/10.1002/ange.201402263" @default.
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