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• W2511208856 abstract "RNA-binding proteins (RBPs) play crucial roles in all organisms. The protein Gemin5 harbors two functional domains. The N-terminal domain binds to snRNAs targeting them for snRNPs assembly, while the C-terminal domain binds to IRES elements through a non-canonical RNA-binding site. Here we report a comprehensive view of the Gemin5 interactome; most partners copurified with the N-terminal domain via RNA bridges. Notably, Gemin5 sediments with the subcellular ribosome fraction, and His-Gemin5 binds to ribosome particles via its N-terminal domain. The interaction with the ribosome was lost in F381A and Y474A Gemin5 mutants, but not in W14A and Y15A. Moreover, the ribosomal proteins L3 and L4 bind directly with Gemin5, and conversely, Gemin5 mutants impairing the binding to the ribosome are defective in the interaction with L3 and L4. The overall polysome profile was affected by Gemin5 depletion or overexpression, concomitant to an increase or a decrease, respectively, of global protein synthesis. Gemin5, and G5-Nter as well, were detected on the polysome fractions. These results reveal the ribosome-binding capacity of the N-ter moiety, enabling Gemin5 to control global protein synthesis. Our study uncovers a crosstalk between this protein and the ribosome, and provides support for the view that Gemin5 may control translation elongation." @default.
• W2511208856 created "2016-09-16" @default.
• W2511208856 creator A5011641798 @default.
• W2511208856 creator A5033445671 @default.
• W2511208856 creator A5040657379 @default.
• W2511208856 creator A5049384441 @default.
• W2511208856 date "2016-08-09" @default.
• W2511208856 modified "2023-10-18" @default.
• W2511208856 title "The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation" @default.
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• W2511208856 doi "https://doi.org/10.1093/nar/gkw702" @default.
• W2511208856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5041490" @default.
• W2511208856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27507887" @default.
• W2511208856 hasPublicationYear "2016" @default.
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