FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511240139> ?p ?o ?g. }

• W2511240139 endingPage "1752" @default.
• W2511240139 startingPage "1748" @default.
• W2511240139 abstract "Objective— Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is expressed on CD4 + effector memory T cells and regulatory T cells; however, its role on these functionally opposing cell types in atherosclerosis is not fully understood. Approach and Results— Low-density lipoprotein receptor–deficient mice ( Ldlr −/− ) were lethally irradiated and reconstituted with either bone marrow from B-cell–restricted Gitrl transgenic mice or from wild-type controls and fed a high-cholesterol diet for 11 weeks. Chimeric Ldlr −/− Gitrl tg mice showed a profound increase in both CD4 + effector memory T cells and regulatory T cells in secondary lymphoid organs. Additionally, the number of regulatory T cells was significantly enhanced in the thymus and aorta of these mice along with increased Gitrl and Il-2 transcript levels. Atherosclerotic lesions of Ldlr −/− Gitrl tg chimeras contained more total CD3 + T cells as well as Foxp3 + regulatory T cells overall, leading to significantly less severe atherosclerosis. Conclusions— These data indicate that continuous GITR stimulation through B cell Gitrl acts protective in a mouse model of atherosclerosis by regulating the balance between regulatory and effector memory CD4 + T cells." @default.
• W2511240139 created "2016-09-16" @default.
• W2511240139 creator A5001023635 @default.
• W2511240139 creator A5001883769 @default.
• W2511240139 creator A5004148771 @default.
• W2511240139 creator A5005489731 @default.
• W2511240139 creator A5011371536 @default.
• W2511240139 creator A5017161801 @default.
• W2511240139 creator A5046414309 @default.
• W2511240139 creator A5057425380 @default.
• W2511240139 creator A5069173292 @default.
• W2511240139 creator A5076844064 @default.
• W2511240139 date "2016-09-01" @default.
• W2511240139 modified "2023-10-17" @default.
• W2511240139 title "Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4 ⁺ T-Cell Responses—Brief Report" @default.
• W2511240139 cites W1517049862 @default.
• W2511240139 cites W1585992677 @default.
• W2511240139 cites W1929235053 @default.
• W2511240139 cites W1996866382 @default.
• W2511240139 cites W1999227421 @default.
• W2511240139 cites W2007089361 @default.
• W2511240139 cites W2019471689 @default.
• W2511240139 cites W2026426963 @default.
• W2511240139 cites W2033746426 @default.
• W2511240139 cites W2035656799 @default.
• W2511240139 cites W2071041688 @default.
• W2511240139 cites W2088422105 @default.
• W2511240139 cites W2120389915 @default.
• W2511240139 cites W2142943268 @default.
• W2511240139 doi "https://doi.org/10.1161/atvbaha.116.307354" @default.
• W2511240139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27444204" @default.
• W2511240139 hasPublicationYear "2016" @default.
• W2511240139 type Work @default.
• W2511240139 sameAs 2511240139 @default.
• W2511240139 citedByCount "26" @default.
• W2511240139 countsByYear W25112401392017 @default.
• W2511240139 countsByYear W25112401392018 @default.
• W2511240139 countsByYear W25112401392019 @default.
• W2511240139 countsByYear W25112401392020 @default.
• W2511240139 countsByYear W25112401392021 @default.
• W2511240139 countsByYear W25112401392022 @default.
• W2511240139 countsByYear W25112401392023 @default.
• W2511240139 crossrefType "journal-article" @default.
• W2511240139 hasAuthorship W2511240139A5001023635 @default.
• W2511240139 hasAuthorship W2511240139A5001883769 @default.
• W2511240139 hasAuthorship W2511240139A5004148771 @default.
• W2511240139 hasAuthorship W2511240139A5005489731 @default.
• W2511240139 hasAuthorship W2511240139A5011371536 @default.
• W2511240139 hasAuthorship W2511240139A5017161801 @default.
• W2511240139 hasAuthorship W2511240139A5046414309 @default.
• W2511240139 hasAuthorship W2511240139A5057425380 @default.
• W2511240139 hasAuthorship W2511240139A5069173292 @default.
• W2511240139 hasAuthorship W2511240139A5076844064 @default.
• W2511240139 hasBestOaLocation W25112401391 @default.
• W2511240139 hasConcept C126322002 @default.
• W2511240139 hasConcept C134018914 @default.
• W2511240139 hasConcept C153911025 @default.
• W2511240139 hasConcept C170493617 @default.
• W2511240139 hasConcept C203014093 @default.
• W2511240139 hasConcept C2776090121 @default.
• W2511240139 hasConcept C2778163477 @default.
• W2511240139 hasConcept C2778296632 @default.
• W2511240139 hasConcept C2779727006 @default.
• W2511240139 hasConcept C2780072125 @default.
• W2511240139 hasConcept C43554185 @default.
• W2511240139 hasConcept C502942594 @default.
• W2511240139 hasConcept C51785407 @default.
• W2511240139 hasConcept C71924100 @default.
• W2511240139 hasConcept C79484868 @default.
• W2511240139 hasConcept C86803240 @default.
• W2511240139 hasConcept C8891405 @default.
• W2511240139 hasConcept C95444343 @default.
• W2511240139 hasConceptScore W2511240139C126322002 @default.
• W2511240139 hasConceptScore W2511240139C134018914 @default.
• W2511240139 hasConceptScore W2511240139C153911025 @default.
• W2511240139 hasConceptScore W2511240139C170493617 @default.
• W2511240139 hasConceptScore W2511240139C203014093 @default.
• W2511240139 hasConceptScore W2511240139C2776090121 @default.
• W2511240139 hasConceptScore W2511240139C2778163477 @default.
• W2511240139 hasConceptScore W2511240139C2778296632 @default.
• W2511240139 hasConceptScore W2511240139C2779727006 @default.
• W2511240139 hasConceptScore W2511240139C2780072125 @default.
• W2511240139 hasConceptScore W2511240139C43554185 @default.
• W2511240139 hasConceptScore W2511240139C502942594 @default.
• W2511240139 hasConceptScore W2511240139C51785407 @default.
• W2511240139 hasConceptScore W2511240139C71924100 @default.
• W2511240139 hasConceptScore W2511240139C79484868 @default.
• W2511240139 hasConceptScore W2511240139C86803240 @default.
• W2511240139 hasConceptScore W2511240139C8891405 @default.
• W2511240139 hasConceptScore W2511240139C95444343 @default.
• W2511240139 hasIssue "9" @default.
• W2511240139 hasLocation W25112401391 @default.
• W2511240139 hasLocation W25112401392 @default.
• W2511240139 hasOpenAccess W2511240139 @default.
• W2511240139 hasPrimaryLocation W25112401391 @default.
• W2511240139 hasRelatedWork W130785812 @default.
• W2511240139 hasRelatedWork W1500755500 @default.
• W2511240139 hasRelatedWork W1510545292 @default.

• next