Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511267427> ?p ?o ?g. }
- W2511267427 abstract "Epstein-Barr virus (EBV) is causally associated with multiple cancers of epithelial and lymphoid origin. Generally, EBV establishes a lifelong quiescent homeostasis (latency) exerting its immune modulating and oncogenic properties only under certain conditions. Lytic replicative EBV infection is restricted to differentiated oropharyngeal epithelia and plasma B-cells. In EBV-associated tumor cells viral gene expression is limited to defined latency programs, without overt virus replication. Artificial triggering of EBV lytic replication with chemical agents (drugs) forms the basis of cytolytic virus activation (CLVA) therapy currently under clinical investigation for treating EBV-positive malignancies. Reactivation from latency requires expression of viral transactivator proteins BZLF1 (Zta) and BRLF1 (Rta). In tumor cells, the BZLF1 promoter (Zp) is highly methylated and generally inactive. However, Zp can be triggered into a self-enhancing activation loop in response to chemical or biological agents, including cytostatic drugs and epigenetic modifiers. This process is orchestrated by Zp-binding cellular transcription factors, such as myocyte enhancer factor 2 (MEF2), specificity protein 1 (SP1), and zinc finger E-box binding homeobox (ZEB) proteins. Understanding the mechanism of lytic induction by chemical inducers is essential for developing effective therapies. This review provide a short overview of EBV biology and will focus on branded and novel agents (drugs) used for EBV lytic induction and discuss molecular mechanisms by which the EBV lytic switch is triggered and controlled." @default.
- W2511267427 created "2016-09-16" @default.
- W2511267427 creator A5085443721 @default.
- W2511267427 date "2016-01-01" @default.
- W2511267427 modified "2023-09-25" @default.
- W2511267427 title "Agents and Approaches for Lytic Induction Therapy of Epstein-Barr Virus Associated Malignancies" @default.
- W2511267427 cites W1274836435 @default.
- W2511267427 cites W143287638 @default.
- W2511267427 cites W1495600034 @default.
- W2511267427 cites W1514597103 @default.
- W2511267427 cites W1532086225 @default.
- W2511267427 cites W1538880474 @default.
- W2511267427 cites W1556928407 @default.
- W2511267427 cites W1578954095 @default.
- W2511267427 cites W1581034919 @default.
- W2511267427 cites W1593352795 @default.
- W2511267427 cites W1743579359 @default.
- W2511267427 cites W1791027840 @default.
- W2511267427 cites W1855274031 @default.
- W2511267427 cites W194837403 @default.
- W2511267427 cites W1964899178 @default.
- W2511267427 cites W1966971174 @default.
- W2511267427 cites W1967018540 @default.
- W2511267427 cites W1967967941 @default.
- W2511267427 cites W1968948902 @default.
- W2511267427 cites W1971168916 @default.
- W2511267427 cites W1971492782 @default.
- W2511267427 cites W1975705914 @default.
- W2511267427 cites W1977971688 @default.
- W2511267427 cites W1978032326 @default.
- W2511267427 cites W1978813972 @default.
- W2511267427 cites W1979401674 @default.
- W2511267427 cites W1984710154 @default.
- W2511267427 cites W1984796464 @default.
- W2511267427 cites W1985124754 @default.
- W2511267427 cites W1986806711 @default.
- W2511267427 cites W1987218682 @default.
- W2511267427 cites W1988472957 @default.
- W2511267427 cites W1988702658 @default.
- W2511267427 cites W1991660464 @default.
- W2511267427 cites W1992103364 @default.
- W2511267427 cites W1993753373 @default.
- W2511267427 cites W1995137396 @default.
- W2511267427 cites W1998948328 @default.
- W2511267427 cites W2003845256 @default.
- W2511267427 cites W2004094927 @default.
- W2511267427 cites W2005437537 @default.
- W2511267427 cites W2006264155 @default.
- W2511267427 cites W2007970538 @default.
- W2511267427 cites W2008340135 @default.
- W2511267427 cites W2008697983 @default.
- W2511267427 cites W2009907388 @default.
- W2511267427 cites W2010358693 @default.
- W2511267427 cites W2010629311 @default.
- W2511267427 cites W2011700755 @default.
- W2511267427 cites W2012420584 @default.
- W2511267427 cites W2012738522 @default.
- W2511267427 cites W2016261254 @default.
- W2511267427 cites W2016980498 @default.
- W2511267427 cites W2017086224 @default.
- W2511267427 cites W2018646661 @default.
- W2511267427 cites W2019044913 @default.
- W2511267427 cites W2021073898 @default.
- W2511267427 cites W2023510440 @default.
- W2511267427 cites W2029932514 @default.
- W2511267427 cites W2030302506 @default.
- W2511267427 cites W2032060490 @default.
- W2511267427 cites W2033768471 @default.
- W2511267427 cites W2039347950 @default.
- W2511267427 cites W2039866061 @default.
- W2511267427 cites W2041551123 @default.
- W2511267427 cites W2041930254 @default.
- W2511267427 cites W2041993478 @default.
- W2511267427 cites W2042610497 @default.
- W2511267427 cites W2043772274 @default.
- W2511267427 cites W2043833032 @default.
- W2511267427 cites W2043971599 @default.
- W2511267427 cites W2045511642 @default.
- W2511267427 cites W2045812345 @default.
- W2511267427 cites W2045838086 @default.
- W2511267427 cites W2045939728 @default.
- W2511267427 cites W2046292205 @default.
- W2511267427 cites W2047776784 @default.
- W2511267427 cites W2051060068 @default.
- W2511267427 cites W2051131460 @default.
- W2511267427 cites W2051965477 @default.
- W2511267427 cites W2052181006 @default.
- W2511267427 cites W2052516925 @default.
- W2511267427 cites W2052908887 @default.
- W2511267427 cites W2053933909 @default.
- W2511267427 cites W2057498074 @default.
- W2511267427 cites W2060998763 @default.
- W2511267427 cites W2061862351 @default.
- W2511267427 cites W2064310618 @default.
- W2511267427 cites W2064345264 @default.
- W2511267427 cites W2065429053 @default.
- W2511267427 cites W2065488621 @default.
- W2511267427 cites W2065998447 @default.
- W2511267427 cites W2066264051 @default.
- W2511267427 cites W2067261441 @default.