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- W2511277237 abstract "The discovery of the bone morphogentic proteins (BMPs) was a big step forward within the knowledge in bone physiology. BMPs are members of a large group of growth factors, the transforming growth factor-β (TGF-β) superfamily. BMPs are growth and differentiation factors which play a pivotal role at all stages in the complex process of embryonic bone formation and adult bone repair. The BMPs stimulate the chemotaxis, proliferation, and differentiation of mesenchymal stem cells resulting in a well controlled formation of bone. Their potential in enhancing bone repair has been demonstrated successfully in animals resulting in the development of BMPs for clinical applications. Before clinical introduction, questions concerning the appropriate dose, carrier delivery system, local and systemic safety had to be addressed, as understanding of the biological and cellular mechanisms of BMPs is essential for their usage in clinical practice." @default.
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- W2511277237 date "2003-01-01" @default.
- W2511277237 modified "2023-10-14" @default.
- W2511277237 title "The Role of Bone Morphogenetic Proteins in Bone Healing" @default.
- W2511277237 doi "https://doi.org/10.1055/s-2003-42606" @default.
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