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- W2511324356 abstract "A functionally modified peptide-conjugated hydrogel system was fabricated with oxidized alginate/gelatin loaded with biphasic calcium phosphate to improve its biocompatibility and functionality. Sodium alginate was treated by controlled oxidation to transform the cis-diol group into an aldehyde group in a controlled manner, which was then conjugated to the amine terminus of glycine–arginine–glycine–aspartic. Oxidized alginate glycine–arginine–glycine–aspartic was then combined with gelatin-loaded biphasic calcium phosphate to form a hydrogel of composite oxidized alginate/gelatin/biphasic calcium phosphate that displayed enhanced human adipose stem cell adhesion, spreading and differentiation. 1 H nuclear magnetic resonance and electron spectroscopy for chemical analysis confirmed that the glycine–arginine–glycine–aspartic was successfully grafted to the oxidized alginate. Co-delivery of glycine–arginine–glycine–aspartic and human adipose stem cell in a hydrogel matrix was studied with the results indicating that hydrogel incorporated modified with glycine–arginine–glycine–aspartic and seeded with human adipose stem cell enhanced osteogenesis in vitro and bone formation in vivo." @default.
- W2511324356 created "2016-09-16" @default.
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- W2511324356 date "2016-09-25" @default.
- W2511324356 modified "2023-10-02" @default.
- W2511324356 title "Augmenting in vitro osteogenesis of a glycine–arginine–glycine–aspartic-conjugated oxidized alginate–gelatin–biphasic calcium phosphate hydrogel composite and in vivo bone biogenesis through stem cell delivery" @default.
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- W2511324356 doi "https://doi.org/10.1177/0885328216667633" @default.
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