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- W2511332855 abstract "We have identified 12 individuals who are heterozygous for a chromosome with three a-globin genes. We determined the presence of the third a-globin locus by restric- tion endonuclease digestion and hybridization with a-globin cDNA probes. The three a-globin loci resided in an elongated fragment on digestion with EcoRI, BamHI, and Xba I, and the third locus was present in an additional 3.7-kilobase fragment on digestion with Hpa I, Sac I, and Bgl II. The locations of the restriction sites are compatible with a nonhomologous crossover mechanism producing the triple a loci. The frequency of the triple a loci was 0.0036 in American blacks and <0.004 in Sar- dinians, but was higher in Greek Cypriots (0.05). Individuals with five a-globin genes (aa/aaa) apparently showed no clinical or hematologic abnormalities." @default.
- W2511332855 created "2016-09-16" @default.
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- W2511332855 date "2016-01-01" @default.
- W2511332855 modified "2023-09-24" @default.
- W2511332855 title "Triplicated a-globin loci in humans (restriction endonuclease mapping/unequal crossing-over/ai thalassemia/polymorphism)" @default.
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