FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511334268> ?p ?o ?g. }

• W2511334268 endingPage "1260" @default.
• W2511334268 startingPage "1249" @default.
• W2511334268 abstract "The association between methylated CDKN2A and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysis Jinyun Li,1,2,* Chongchang Zhou,1,* Haojie Zhou,3,* Tianlian Bao,1 Tengjiao Gao,1 Xiangling Jiang,1 Meng Ye1,2 1Department of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, 2Department of Medical Oncology, Affiliated Hospital, Ningbo University, 3Department of Molecular Diagnosis, Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang, People’s Republic of China *These authors are co-first authors of this work Background: Cervical cancer is the second deadliest gynecologic malignancy, characterized by apparently precancerous lesions and cervical intraepithelial neoplasia (CIN), and having a long course from the development of CIN to cervical cancer. Cyclin-dependent kinase inhibitor 2A (CDKN2A) is a well-documented tumor suppressor gene and is commonly methylated in cervical cancer. However, the relationship between methylated CDKN2A and carcinogenesis in cervical cancer is inconsistent, and the diagnostic accuracy of methylated CDKN2A is underinvestigated. In this study, we attempted to quantify the association between CDKN2A methylation and the carcinogenesis of cervical cancer, and its diagnostic power.Methods: We systematically reviewed four electronic databases and identified 26 studies involving 1,490 cervical cancers, 1,291 CINs, and 964 controls. A pooled odds ratio (OR) with corresponding 95% confidence intervals (95% CI) was calculated to evaluate the association between methylated CDKN2A and the carcinogenesis of cervical cancer. Specificity, sensitivity, the area under the receiver operating characteristic curve, and the diagnostic odds ratio were computed to assess the effect of methylated CDKN2A in the diagnosis of cervical cancer.Results: Our results indicated an upward trend in the methylation frequency of CDKN2A in the carcinogenesis of cervical cancer (cancer vs control: OR =23.67, 95% CI =15.54–36.06; cancer vs CIN: OR =2.53, 95% CI =1.79–3.5; CIN vs control: OR =9.68, 95% CI =5.82–16.02). The specificity, sensitivity, area under the receiver operating characteristic curve, and diagnostic odds ratio were 0.99 (95% CI: 0.97–0.99), 0.36 (95% CI: 0.28–0.45), 0.93 (95% CI: 0.91–0.95), and 43 (95% CI: 19–98), respectively.Conclusion: Our findings indicate that abnormal CDKN2A methylation may be strongly correlated with the pathogenesis of cervical cancer. Our results also demonstrate that CDKN2A methylation might serve as an early detector of cervical cancer. These findings require further confirmation. Keywords: p16, methylation, cervical cancer carcinogenesis" @default.
• W2511334268 created "2016-09-16" @default.
• W2511334268 creator A5000399206 @default.
• W2511334268 creator A5021240812 @default.
• W2511334268 creator A5026104277 @default.
• W2511334268 creator A5033070500 @default.
• W2511334268 creator A5037367417 @default.
• W2511334268 creator A5052899933 @default.
• W2511334268 creator A5072391290 @default.
• W2511334268 date "2016-08-01" @default.
• W2511334268 modified "2023-09-26" @default.
• W2511334268 title "The association between methylated <em>CDKN2A</em> and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysis" @default.
• W2511334268 cites W1516326873 @default.
• W2511334268 cites W1536790368 @default.
• W2511334268 cites W1556996865 @default.
• W2511334268 cites W1592215560 @default.
• W2511334268 cites W1945270539 @default.
• W2511334268 cites W1960196749 @default.
• W2511334268 cites W1965709611 @default.
• W2511334268 cites W1972249702 @default.
• W2511334268 cites W1979362779 @default.
• W2511334268 cites W1982098134 @default.
• W2511334268 cites W1987052527 @default.
• W2511334268 cites W1987350137 @default.
• W2511334268 cites W1991558062 @default.
• W2511334268 cites W1993737607 @default.
• W2511334268 cites W2001480633 @default.
• W2511334268 cites W2001986719 @default.
• W2511334268 cites W2008937722 @default.
• W2511334268 cites W2011433199 @default.
• W2511334268 cites W2014652416 @default.
• W2511334268 cites W2024558578 @default.
• W2511334268 cites W2033585778 @default.
• W2511334268 cites W2036190704 @default.
• W2511334268 cites W2036986058 @default.
• W2511334268 cites W2042755822 @default.
• W2511334268 cites W2046284837 @default.
• W2511334268 cites W2046387526 @default.
• W2511334268 cites W2046528914 @default.
• W2511334268 cites W2046974465 @default.
• W2511334268 cites W2058088950 @default.
• W2511334268 cites W2063807050 @default.
• W2511334268 cites W2066848701 @default.
• W2511334268 cites W2068394634 @default.
• W2511334268 cites W2071994576 @default.
• W2511334268 cites W2074137258 @default.
• W2511334268 cites W2081398080 @default.
• W2511334268 cites W2086492419 @default.
• W2511334268 cites W2092926517 @default.
• W2511334268 cites W2097220249 @default.
• W2511334268 cites W2098141312 @default.
• W2511334268 cites W2098765233 @default.
• W2511334268 cites W2104960492 @default.
• W2511334268 cites W2105428856 @default.
• W2511334268 cites W2110511887 @default.
• W2511334268 cites W2112031808 @default.
• W2511334268 cites W2113155233 @default.
• W2511334268 cites W2135550671 @default.
• W2511334268 cites W2136156766 @default.
• W2511334268 cites W2155950537 @default.
• W2511334268 cites W2167009343 @default.
• W2511334268 cites W2171197897 @default.
• W2511334268 cites W2272984102 @default.
• W2511334268 cites W2275873793 @default.
• W2511334268 cites W2396200706 @default.
• W2511334268 cites W2413409196 @default.
• W2511334268 cites W4250670238 @default.
• W2511334268 doi "https://doi.org/10.2147/tcrm.s108094" @default.
• W2511334268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4994797" @default.
• W2511334268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27574435" @default.
• W2511334268 hasPublicationYear "2016" @default.
• W2511334268 type Work @default.
• W2511334268 sameAs 2511334268 @default.
• W2511334268 citedByCount "11" @default.
• W2511334268 countsByYear W25113342682018 @default.
• W2511334268 countsByYear W25113342682019 @default.
• W2511334268 countsByYear W25113342682020 @default.
• W2511334268 countsByYear W25113342682021 @default.
• W2511334268 countsByYear W25113342682023 @default.
• W2511334268 crossrefType "journal-article" @default.
• W2511334268 hasAuthorship W2511334268A5000399206 @default.
• W2511334268 hasAuthorship W2511334268A5021240812 @default.
• W2511334268 hasAuthorship W2511334268A5026104277 @default.
• W2511334268 hasAuthorship W2511334268A5033070500 @default.
• W2511334268 hasAuthorship W2511334268A5037367417 @default.
• W2511334268 hasAuthorship W2511334268A5052899933 @default.
• W2511334268 hasAuthorship W2511334268A5072391290 @default.
• W2511334268 hasBestOaLocation W25113342681 @default.
• W2511334268 hasConcept C121608353 @default.
• W2511334268 hasConcept C126322002 @default.
• W2511334268 hasConcept C143998085 @default.
• W2511334268 hasConcept C156957248 @default.
• W2511334268 hasConcept C157481446 @default.
• W2511334268 hasConcept C2777343196 @default.
• W2511334268 hasConcept C2778220009 @default.
• W2511334268 hasConcept C2780265364 @default.
• W2511334268 hasConcept C502942594 @default.
• W2511334268 hasConcept C555283112 @default.

• next