FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511351625> ?p ?o ?g. }

• W2511351625 abstract "Formins are a highly conserved family of cytoskeletal remodeling proteins. A growing body of evidence suggests that formins play key roles in the progression and spread of a variety of cancers. There are 15 human formin proteins and of these the Diaphanous-Related Formins (DRFs) are the best characterized. Included in the DRFs are the Formin-Like proteins, FMNL1, 2 & 3, each of which have been strongly implicated in driving tumorigenesis and metastasis of specific tumors. In particular, increased FMNL2 expression correlates with increased invasiveness of colorectal cancer (CRC) in vivo and for a variety of CRC cell-lines in vitro. FMNL2 expression is also required for invasive cell motility in other cancer cell-lines. There are multiple alternatively spliced isoforms of FMNL2 and it is predicted that the encoded proteins will differ in their regulation, subcellular localization and in their ability to regulate cytoskeletal dynamics.Using RT-PCR we identified four FMNL2 isoforms expressed in CRC and melanoma cell-lines. We find that a previously uncharacterized FMNL2 isoform is predominantly expressed in a variety of melanoma and CRC cell lines; this isoform is also more effective in driving 3D motility. Building on previous reports, we also show that FMNL2 is required for invasion in A375 and WM266.4 melanoma cells.Taken together, these results suggest that FMNL2 is likely to be generally required in melanoma cells for invasion, that a specific isoform of FMNL2 is up-regulated in invasive CRC and melanoma cells and this isoform is the most effective at facilitating invasion." @default.
• W2511351625 created "2016-09-16" @default.
• W2511351625 creator A5007946105 @default.
• W2511351625 creator A5022905294 @default.
• W2511351625 creator A5036564036 @default.
• W2511351625 creator A5041448352 @default.
• W2511351625 creator A5057281195 @default.
• W2511351625 date "2016-08-30" @default.
• W2511351625 modified "2023-10-12" @default.
• W2511351625 title "A specific FMNL2 isoform is up-regulated in invasive cells" @default.
• W2511351625 cites W1571559775 @default.
• W2511351625 cites W1733759343 @default.
• W2511351625 cites W1949091651 @default.
• W2511351625 cites W1965174161 @default.
• W2511351625 cites W1973291656 @default.
• W2511351625 cites W1980525108 @default.
• W2511351625 cites W1989076816 @default.
• W2511351625 cites W1989309829 @default.
• W2511351625 cites W1993323164 @default.
• W2511351625 cites W1999301185 @default.
• W2511351625 cites W2006502967 @default.
• W2511351625 cites W2007504351 @default.
• W2511351625 cites W2012948303 @default.
• W2511351625 cites W2013718744 @default.
• W2511351625 cites W2016727199 @default.
• W2511351625 cites W2030905683 @default.
• W2511351625 cites W2044788731 @default.
• W2511351625 cites W2059469253 @default.
• W2511351625 cites W2065802258 @default.
• W2511351625 cites W2066486192 @default.
• W2511351625 cites W2072171625 @default.
• W2511351625 cites W2080422007 @default.
• W2511351625 cites W2083543572 @default.
• W2511351625 cites W2086641174 @default.
• W2511351625 cites W2088071645 @default.
• W2511351625 cites W2091995773 @default.
• W2511351625 cites W2098589170 @default.
• W2511351625 cites W2098996804 @default.
• W2511351625 cites W2100380705 @default.
• W2511351625 cites W2100939731 @default.
• W2511351625 cites W2101002731 @default.
• W2511351625 cites W2102640342 @default.
• W2511351625 cites W2104293024 @default.
• W2511351625 cites W2107926106 @default.
• W2511351625 cites W2113179909 @default.
• W2511351625 cites W2132276924 @default.
• W2511351625 cites W2134250091 @default.
• W2511351625 cites W2135453326 @default.
• W2511351625 cites W2137122394 @default.
• W2511351625 cites W2143058121 @default.
• W2511351625 cites W2143997699 @default.
• W2511351625 cites W2147554103 @default.
• W2511351625 cites W2149259704 @default.
• W2511351625 cites W2163858320 @default.
• W2511351625 cites W2165369804 @default.
• W2511351625 cites W2195889498 @default.
• W2511351625 doi "https://doi.org/10.1186/s12860-016-0110-z" @default.
• W2511351625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5006604" @default.
• W2511351625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27578625" @default.
• W2511351625 hasPublicationYear "2016" @default.
• W2511351625 type Work @default.
• W2511351625 sameAs 2511351625 @default.
• W2511351625 citedByCount "12" @default.
• W2511351625 countsByYear W25113516252017 @default.
• W2511351625 countsByYear W25113516252018 @default.
• W2511351625 countsByYear W25113516252019 @default.
• W2511351625 countsByYear W25113516252020 @default.
• W2511351625 countsByYear W25113516252021 @default.
• W2511351625 countsByYear W25113516252022 @default.
• W2511351625 countsByYear W25113516252023 @default.
• W2511351625 crossrefType "journal-article" @default.
• W2511351625 hasAuthorship W2511351625A5007946105 @default.
• W2511351625 hasAuthorship W2511351625A5022905294 @default.
• W2511351625 hasAuthorship W2511351625A5036564036 @default.
• W2511351625 hasAuthorship W2511351625A5041448352 @default.
• W2511351625 hasAuthorship W2511351625A5057281195 @default.
• W2511351625 hasBestOaLocation W25113516251 @default.
• W2511351625 hasConcept C104317684 @default.
• W2511351625 hasConcept C121608353 @default.
• W2511351625 hasConcept C125705527 @default.
• W2511351625 hasConcept C142669718 @default.
• W2511351625 hasConcept C1491633281 @default.
• W2511351625 hasConcept C2777658100 @default.
• W2511351625 hasConcept C2779013556 @default.
• W2511351625 hasConcept C2993400109 @default.
• W2511351625 hasConcept C502942594 @default.
• W2511351625 hasConcept C526805850 @default.
• W2511351625 hasConcept C53195969 @default.
• W2511351625 hasConcept C53345823 @default.
• W2511351625 hasConcept C54355233 @default.
• W2511351625 hasConcept C555283112 @default.
• W2511351625 hasConcept C58207958 @default.
• W2511351625 hasConcept C86803240 @default.
• W2511351625 hasConcept C95444343 @default.
• W2511351625 hasConceptScore W2511351625C104317684 @default.
• W2511351625 hasConceptScore W2511351625C121608353 @default.
• W2511351625 hasConceptScore W2511351625C125705527 @default.
• W2511351625 hasConceptScore W2511351625C142669718 @default.
• W2511351625 hasConceptScore W2511351625C1491633281 @default.
• W2511351625 hasConceptScore W2511351625C2777658100 @default.

• next