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- W2511382289 abstract "We proposed an investigation of genetically-determined individual differences in sensitivity to ionizing radiation. The model organism is Drosophila melanogaster. The gene coding for Cu, Zn superoxide dismutase (SOD) is the target locus, but the effects of variation in other components of the genome that modulate SOD levels are also taken into account. SOD scavenges oxygen radicals generated during exposure to ionizing radiation. It has been shown to protect against ionizing radiation damage to DNA, viruses, bacteria, mammalian cells, whole mice, and Drosophila. Two alleles, S and F, are commonly found in natural populations of D. melanogaster; in addition we have isolated from a natural population of ``null`` (CA1) mutant that yields only 3.5% of normal SOD activity. The S, F, and CA1 alleles provide an ideal model system to investigate SOD-dependent radioresistance, because each allele yields different levels of SOD, so that S > F >> CA1. The role of SOD levels in radioresistance are being investigated in a series of experiments that measure the somatic and germ-line effects of increasing doses of ionizing radiation. During the first seven months of funding we have completed a number of experiments and are proceeding with many others. We have made progress along all the research lines anticipated for the first year of this grant, as summarized in the following pages." @default.
- W2511382289 created "2016-09-16" @default.
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- W2511382289 date "1990-12-31" @default.
- W2511382289 modified "2023-09-27" @default.
- W2511382289 title "Genetic variation in resistance to ionizing radiation. Progress report, January--July 1990" @default.
- W2511382289 doi "https://doi.org/10.2172/10116222" @default.
- W2511382289 hasPublicationYear "1990" @default.
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