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- W2511382322 abstract "In actively growing E. coli cells, most of the transcription activity is driven by the housekeeping sigma factor (σ70). The association of σ70 with core RNAP is favored over alternative sigma factors because of its higher abundance and better binding affinity to core RNAP. During stress or starvation, the transcriptional switchover to alternative sigma factors is achieved by the bacterial cell by utilizing multiple strategies due to which the σ70-driven transcription is diminished in a reversible manner. The molecular mechanism of shifting the balance toward transcription by alternative sigma factors involves a number of small and large molecules, including the alarmone (p)ppGpp (represents ppGpp or pppGpp), proteins (DksA and Rsd), and a species of small RNA (6S RNA). Despite being known for a long time, the role of 6S RNA and (p)ppGpp in regulation of transcription has been understood only in recent years. With the functional characterization of Rsd and DksA, new mechanisms of downregulating proliferation-related transcription have been uncovered. As the physiological outcomes of actions of (p)ppGpp, 6S RNA, DksA, and Rsd are similar, it is vital to analyze the functions of these molecules together. The recent trends in understanding the regulation of σ70-driven transcription by (p)ppGpp, DksA, Rsd, and 6S RNA are reviewed, and complexities of RNAP redistribution during stress and starvation by modulation of σ70 activity in E. coli are analyzed." @default.
- W2511382322 created "2016-09-16" @default.
- W2511382322 creator A5024876780 @default.
- W2511382322 date "2016-08-12" @default.
- W2511382322 modified "2023-09-23" @default.
- W2511382322 title "Role of Changes in σ70-Driven Transcription in Adaptation ofE. colito Conditions of Stress or Starvation" @default.
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- W2511382322 doi "https://doi.org/10.1002/9781119004813.ch5" @default.
- W2511382322 hasPublicationYear "2016" @default.
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