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- W2511439248 abstract "Efforts to investigate the progression of events that cause human cells to become neoplastic in response to ionizing radiation have been aided by the development of tissue culture systems of epithelial cells. In the present study, nontumorigenic human epidermal keratinocytes immortalized by adenovirus type 12 and simian virus 40 have been trans- formed by exposure to x-ray irradiation. Such transformants showed morphological alterations, formed colonies in soft agar, and induced carcinomas when transplanted into nude mice, whereas primary human epidermal keratinocytes exposed to radiation in this manner failed to show any evidence of transformation. These findings demonstrate the malignant transformation of human primary epithelial cells in culture by the combined action of a DNA tumor virus and radiation, indicating a multistep process for radiation-induced neoplastic conversion. This in vitro system may be useful as a tool for dissecting the process of radiation-induced neoplastic transfor- mation of human epithelial cells and for detecting previously unreported human oncogenes." @default.
- W2511439248 created "2016-09-16" @default.
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- W2511439248 date "2016-01-01" @default.
- W2511439248 modified "2023-09-28" @default.
- W2511439248 title "Neoplastic transformation of immortalized human epidermal keratinocytes by ionizing radiation (radiation carcinogenesis/adenovirus type 12/simian virus 40/p21/malignant transformation)" @default.
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