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• W2511456449 abstract "Objective . The study aimed at locating and quantifying Toll Like Receptor (TLR) 3, 7, 8, and 9 expression in kidney of patients with lupus nephritis (LN) and correlating them with clinicopathological features. Methods . Kidney sections from 26 LN patients and 4 controls were analyzed by immunohistochemistry using anti-human TLR3, TLR7, TLR8, and TLR9 polyclonal antibodies; the number of TLR-positive nuclei/mm 2 was evaluated on digitalized images. Results . Compared to controls, LN showed a significantly higher amount of glomerular and tubulointerstitial TLR9 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.003</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.007</mml:mn></mml:math>), whole and tubulointerstitial TLR3 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.026</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.031</mml:mn></mml:math>), and a higher tubulointerstitial TLR7 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.022</mml:mn></mml:math>). TLR9 positively correlated with activity index (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.0063</mml:mn></mml:math>) and tubular TLR7 with chronicity index (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.026</mml:mn></mml:math>). TLR9 positively correlated with Renal-SLEDAI (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.01</mml:mn></mml:math>). Conclusions . This is the first study quantifying kidney expressions of TLRs in LN patients; the results show an overexpression of TLR3, TLR7, and TLR9 and demonstrate a correlation with clinicopathological indices supporting a role of these mediators in the pathogenesis of LN." @default.
• W2511456449 created "2016-09-16" @default.
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• W2511456449 date "2016-01-01" @default.
• W2511456449 modified "2023-10-12" @default.
• W2511456449 title "Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations" @default.
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• W2511456449 doi "https://doi.org/10.1155/2016/7697592" @default.
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