FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511483346> ?p ?o ?g. }

• W2511483346 endingPage "e0004991" @default.
• W2511483346 startingPage "e0004991" @default.
• W2511483346 abstract "T cells are known to contribute to immune protection against scrub typhus, a potentially fatal infection caused by the obligate intracellular bacterium Orientia (O.) tsutsugamushi. However, the contribution of CD8+ T cells to protection and pathogenesis during O. tsutsugamushi infection is still unknown. Using our recently developed BALB/c mouse model that is based on footpad inoculation of the human-pathogenic Karp strain, we show that activated CD8+ T cells infiltrate spleen and lung during the third week of infection. Depletion of CD8+ T cells with monoclonal antibodies resulted in uncontrolled pathogen growth and mortality. Adoptive transfer of CD8+ T cells from infected animals protected naïve BALB/c mice from lethal outcome of intraperitoneal challenge. In C57Bl/6 mice, the pulmonary lymphocyte compartment showed an increased percentage of CD8+ T cells for at least 135 days post O. tsutsugamushi infection. Depletion of CD8+ T cells at 84 days post infection caused reactivation of bacterial growth. In CD8+ T cell-deficient beta 2-microglobulin knockout mice, bacterial replication was uncontrolled, and all mice succumbed to the infection, despite higher serum IFN-γ levels and stronger macrophage responses in liver and lung. Moreover, we show that CD8+ T cells but not NKT cells were required for hepatocyte injury: elevated concentrations of serum alanine aminotransferase and infection-induced subcapsular necrotic liver lesions surrounded by macrophages were found in C57Bl/6 and CD1d-deficient mice, but not in beta 2-microglobulin knockout mice. In the lungs, peribronchial macrophage infiltrations also depended on CD8+ T cells. In summary, our results demonstrate that CD8+ T cells restrict growth of O. tsutsugamushi during acute and persistent infection, and are required to protect from lethal infections in BALB/c and C57BL/6 mice. However, they also elicit specific pathologic tissue lesions in liver and lung." @default.
• W2511483346 created "2016-09-16" @default.
• W2511483346 creator A5009281017 @default.
• W2511483346 creator A5011269591 @default.
• W2511483346 creator A5046014100 @default.
• W2511483346 creator A5052392618 @default.
• W2511483346 creator A5053700057 @default.
• W2511483346 creator A5078545605 @default.
• W2511483346 creator A5087449730 @default.
• W2511483346 date "2016-09-08" @default.
• W2511483346 modified "2023-10-12" @default.
• W2511483346 title "Protective and Pathogenic Roles of CD8+ T Lymphocytes in Murine Orientia tsutsugamushi Infection" @default.
• W2511483346 cites W110885378 @default.
• W2511483346 cites W1498617252 @default.
• W2511483346 cites W1506623892 @default.
• W2511483346 cites W1547559400 @default.
• W2511483346 cites W1553763518 @default.
• W2511483346 cites W1556311053 @default.
• W2511483346 cites W1669573844 @default.
• W2511483346 cites W1761128998 @default.
• W2511483346 cites W1817525431 @default.
• W2511483346 cites W1824944711 @default.
• W2511483346 cites W1854219575 @default.
• W2511483346 cites W1926016279 @default.
• W2511483346 cites W1930609608 @default.
• W2511483346 cites W1966649886 @default.
• W2511483346 cites W1967927764 @default.
• W2511483346 cites W1968508276 @default.
• W2511483346 cites W1968693370 @default.
• W2511483346 cites W1971786258 @default.
• W2511483346 cites W1972825236 @default.
• W2511483346 cites W1973737374 @default.
• W2511483346 cites W1975244910 @default.
• W2511483346 cites W1975665532 @default.
• W2511483346 cites W1976608939 @default.
• W2511483346 cites W1981591073 @default.
• W2511483346 cites W1985260830 @default.
• W2511483346 cites W1992919103 @default.
• W2511483346 cites W1996295543 @default.
• W2511483346 cites W2008276095 @default.
• W2511483346 cites W2013370642 @default.
• W2511483346 cites W2020118398 @default.
• W2511483346 cites W2021497905 @default.
• W2511483346 cites W2022712113 @default.
• W2511483346 cites W2024180247 @default.
• W2511483346 cites W2025153365 @default.
• W2511483346 cites W2045098554 @default.
• W2511483346 cites W2052056990 @default.
• W2511483346 cites W2054968862 @default.
• W2511483346 cites W2064295826 @default.
• W2511483346 cites W2067648924 @default.
• W2511483346 cites W2079039118 @default.
• W2511483346 cites W2088719567 @default.
• W2511483346 cites W2092588056 @default.
• W2511483346 cites W2099642944 @default.
• W2511483346 cites W2106238650 @default.
• W2511483346 cites W2109707657 @default.
• W2511483346 cites W2110514337 @default.
• W2511483346 cites W2112759197 @default.
• W2511483346 cites W2115038384 @default.
• W2511483346 cites W2115435948 @default.
• W2511483346 cites W2121542748 @default.
• W2511483346 cites W2121965223 @default.
• W2511483346 cites W2122918913 @default.
• W2511483346 cites W2126728789 @default.
• W2511483346 cites W2130121394 @default.
• W2511483346 cites W2131607477 @default.
• W2511483346 cites W2139249270 @default.
• W2511483346 cites W2146908925 @default.
• W2511483346 cites W2152644554 @default.
• W2511483346 cites W2160938075 @default.
• W2511483346 cites W2162204022 @default.
• W2511483346 cites W2162395579 @default.
• W2511483346 cites W2162897356 @default.
• W2511483346 cites W2165897088 @default.
• W2511483346 cites W2168217071 @default.
• W2511483346 cites W2170306097 @default.
• W2511483346 cites W2290712233 @default.
• W2511483346 cites W2291694515 @default.
• W2511483346 cites W2297017972 @default.
• W2511483346 cites W2317289516 @default.
• W2511483346 cites W2399541234 @default.
• W2511483346 cites W2412889589 @default.
• W2511483346 cites W4313387071 @default.
• W2511483346 doi "https://doi.org/10.1371/journal.pntd.0004991" @default.
• W2511483346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5015871" @default.
• W2511483346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27606708" @default.
• W2511483346 hasPublicationYear "2016" @default.
• W2511483346 type Work @default.
• W2511483346 sameAs 2511483346 @default.
• W2511483346 citedByCount "31" @default.
• W2511483346 countsByYear W25114833462017 @default.
• W2511483346 countsByYear W25114833462018 @default.
• W2511483346 countsByYear W25114833462019 @default.
• W2511483346 countsByYear W25114833462020 @default.
• W2511483346 countsByYear W25114833462021 @default.
• W2511483346 countsByYear W25114833462022 @default.
• W2511483346 countsByYear W25114833462023 @default.

• next