FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511484889> ?p ?o ?g. }

• W2511484889 endingPage "145" @default.
• W2511484889 startingPage "138" @default.
• W2511484889 abstract "Abstract Erythropoietin is a potent stimulator of erythroid progenitor cells, which is able to inhibit NF ‐ kB activation, due to its pleiotropic properties, thus promoting an anti‐inflammatory effect. As inflammatory bowel disease is a chronic disease with reduced quality of life, and the current pharmacotherapy only induces or maintains the patient in remission, there is a crucial need of new pharmacological approaches. The main objective of this study was to evaluate the effect of erythropoietin in the TNBS ‐induced colitis model in mice with a normal intestinal flora. Mice with TNBS ‐induced colitis were treated with a daily dose of erythropoietin at 500 IU /kg bw/day and 1000 IU /Kg bw/day IP during 4 days. As to clinical symptoms/signs, erythropoietin attenuated the decreased body‐weight and reduced diarrhoea and oedema of the anus registered in the non‐treated mice group in a dose‐dependent manner. The anti‐inflammatory properties of erythropoietin in the TNBS ‐induced colitis were confirmed by suppression of pro‐inflammatory mediators, such as TNF ‐α, IL ‐1β and MPO , as well as a significant increase in the anti‐inflammatory cytokine, IL ‐10, was promoted. These treated mice also presented a reduction in haemoglobin faecal and ALP , suggesting a beneficial effect of erythropoietin in the haemorrhagic focus and destruction of the enterocyte associated with the colon injury induced by TNBS , respectively. The histopathological score was reduced after treatment with erythropoietin, decreasing the severity and extension of the colitis. Furthermore, renal and hepatic biomarkers, as well as haematocrit concentration, remained stabilized after treatment. In conclusion, erythropoietin reduces the inflammatory response associated with TNBS ‐induced colitis in mice." @default.
• W2511484889 created "2016-09-16" @default.
• W2511484889 creator A5009788760 @default.
• W2511484889 creator A5013391943 @default.
• W2511484889 creator A5053708333 @default.
• W2511484889 creator A5054797240 @default.
• W2511484889 creator A5083171867 @default.
• W2511484889 creator A5087016269 @default.
• W2511484889 date "2016-11-23" @default.
• W2511484889 modified "2023-10-16" @default.
• W2511484889 title "Anti‐Inflammatory Effect of Erythropoietin in the <scp>TNBS</scp>‐induced Colitis" @default.
• W2511484889 cites W1523941392 @default.
• W2511484889 cites W1972071510 @default.
• W2511484889 cites W1978726693 @default.
• W2511484889 cites W1980392852 @default.
• W2511484889 cites W1985866220 @default.
• W2511484889 cites W1994756617 @default.
• W2511484889 cites W1996905338 @default.
• W2511484889 cites W1999784325 @default.
• W2511484889 cites W2005956916 @default.
• W2511484889 cites W2016827484 @default.
• W2511484889 cites W2040761085 @default.
• W2511484889 cites W2055539643 @default.
• W2511484889 cites W2057447694 @default.
• W2511484889 cites W2058930880 @default.
• W2511484889 cites W2059115670 @default.
• W2511484889 cites W2060373663 @default.
• W2511484889 cites W2063157795 @default.
• W2511484889 cites W2067736355 @default.
• W2511484889 cites W2071250578 @default.
• W2511484889 cites W2080043456 @default.
• W2511484889 cites W2083151325 @default.
• W2511484889 cites W2088051520 @default.
• W2511484889 cites W2099156985 @default.
• W2511484889 cites W2104514849 @default.
• W2511484889 cites W2107201542 @default.
• W2511484889 cites W2108229642 @default.
• W2511484889 cites W2108712459 @default.
• W2511484889 cites W2113427789 @default.
• W2511484889 cites W2113517130 @default.
• W2511484889 cites W2114387870 @default.
• W2511484889 cites W2152477961 @default.
• W2511484889 cites W2155220483 @default.
• W2511484889 cites W2155322739 @default.
• W2511484889 cites W2156250460 @default.
• W2511484889 cites W2165545496 @default.
• W2511484889 cites W2168184580 @default.
• W2511484889 cites W2168485813 @default.
• W2511484889 cites W2168867226 @default.
• W2511484889 cites W2170023789 @default.
• W2511484889 cites W2406155517 @default.
• W2511484889 doi "https://doi.org/10.1111/bcpt.12663" @default.
• W2511484889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27579991" @default.
• W2511484889 hasPublicationYear "2016" @default.
• W2511484889 type Work @default.
• W2511484889 sameAs 2511484889 @default.
• W2511484889 citedByCount "23" @default.
• W2511484889 countsByYear W25114848892017 @default.
• W2511484889 countsByYear W25114848892018 @default.
• W2511484889 countsByYear W25114848892019 @default.
• W2511484889 countsByYear W25114848892020 @default.
• W2511484889 countsByYear W25114848892021 @default.
• W2511484889 countsByYear W25114848892022 @default.
• W2511484889 countsByYear W25114848892023 @default.
• W2511484889 crossrefType "journal-article" @default.
• W2511484889 hasAuthorship W2511484889A5009788760 @default.
• W2511484889 hasAuthorship W2511484889A5013391943 @default.
• W2511484889 hasAuthorship W2511484889A5053708333 @default.
• W2511484889 hasAuthorship W2511484889A5054797240 @default.
• W2511484889 hasAuthorship W2511484889A5083171867 @default.
• W2511484889 hasAuthorship W2511484889A5087016269 @default.
• W2511484889 hasBestOaLocation W25114848891 @default.
• W2511484889 hasConcept C126322002 @default.
• W2511484889 hasConcept C203014093 @default.
• W2511484889 hasConcept C2775862500 @default.
• W2511484889 hasConcept C2776914184 @default.
• W2511484889 hasConcept C2778260677 @default.
• W2511484889 hasConcept C2778534260 @default.
• W2511484889 hasConcept C2778690821 @default.
• W2511484889 hasConcept C2779134260 @default.
• W2511484889 hasConcept C2780479503 @default.
• W2511484889 hasConcept C71924100 @default.
• W2511484889 hasConcept C90924648 @default.
• W2511484889 hasConcept C98274493 @default.
• W2511484889 hasConceptScore W2511484889C126322002 @default.
• W2511484889 hasConceptScore W2511484889C203014093 @default.
• W2511484889 hasConceptScore W2511484889C2775862500 @default.
• W2511484889 hasConceptScore W2511484889C2776914184 @default.
• W2511484889 hasConceptScore W2511484889C2778260677 @default.
• W2511484889 hasConceptScore W2511484889C2778534260 @default.
• W2511484889 hasConceptScore W2511484889C2778690821 @default.
• W2511484889 hasConceptScore W2511484889C2779134260 @default.
• W2511484889 hasConceptScore W2511484889C2780479503 @default.
• W2511484889 hasConceptScore W2511484889C71924100 @default.
• W2511484889 hasConceptScore W2511484889C90924648 @default.
• W2511484889 hasConceptScore W2511484889C98274493 @default.
• W2511484889 hasIssue "2" @default.
• W2511484889 hasLocation W25114848891 @default.

• next