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- W2511489087 abstract "The toxicity of talampicillin hydrochloride, a new orally active ampicillin derivative, was studied in beagle dogs of both sexes. The drug was orally administered to the dogs at dose levels of 0, 30, 100 and 300 mg/kg/day for five weeks.The dogs given 30 mg/kg/day developed no clinical symptoms suggestive of drug toxicity. Most of dogs receiving 100 and 300 mg/kg/day showed vomiting during the first week, incidence of which gradually decreased, and became rare from the third week on.No significant changes were observed in body weights, food consumption, hematological and biochemical findings and organ weights.No pathological changes due to drug action were detected by macroscopic and histological examinations." @default.
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- W2511489087 date "1975-01-01" @default.
- W2511489087 modified "2023-10-05" @default.
- W2511489087 title "Toxicological Studies of Talampicillin Hydrochloride (TAPC)" @default.
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- W2511489087 doi "https://doi.org/10.11150/kansenshogakuzasshi1970.49.746" @default.
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