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- W2511549215 abstract "Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are produced by essentially all eukaryotes and are highly diverse in their sequences and structures. Most display broad range antimicrobial activity at low micromolar concentrations, whereas others have other diverse roles, including cell signalling (e.g. immune cell recruitment, self/non-self-recognition), ion channel perturbation, toxic functions, and enzyme inhibition. The defensins consist of two superfamilies, each derived from an independent evolutionary origin, which have subsequently undergone extensive divergent evolution in their sequence, structure and function. Referred to as the cis- and trans-defensin superfamilies, they are classified based on their secondary structure orientation, cysteine motifs and disulphide bond connectivities, tertiary structure similarities and precursor gene sequence. The utility of displaying loops on a stable, compact, disulphide-rich core has been exploited by evolution on multiple occasions. The defensin superfamilies represent a case where the ensuing convergent evolution of sequence, structure and function has been particularly extreme. Here, we discuss the extent, causes and significance of these convergent features, drawing examples from across the eukaryotes." @default.
- W2511549215 created "2016-09-16" @default.
- W2511549215 creator A5037467309 @default.
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- W2511549215 creator A5079020649 @default.
- W2511549215 creator A5081266713 @default.
- W2511549215 creator A5089817671 @default.
- W2511549215 date "2016-08-24" @default.
- W2511549215 modified "2023-10-09" @default.
- W2511549215 title "Convergent evolution of defensin sequence, structure and function" @default.
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