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• W2511589291 abstract "Pharmacognosy Research,2016,8,4,292-297.DOI:10.4103/0974-8490.188886Published:August 2016Type:Original ArticleAuthors:Yasotha Devi Muthiah, Chin Eng Ong, Siti Amrah Sulaiman, and Rusli Ismail Author(s) affiliations:Yasotha Devi Muthiah1, Chin Eng Ong2, Siti Amrah Sulaiman3, Rusli Ismail4 1Pharmacogenetics Research Group, Institute for Research in Molecular Medicine, Universiti Sains, MALAYSIA. 2School of Pharmacy, Monash University , 47500 Bandar Sunway, Selangor, MALAYSIA. 3Department of Pharmacology, School of Medical Sciences, Universiti Sains , 16150 Kubang Kerian, Kelantan,MALAYSIA. 4Centre of Excellence for Research in AIDS, Universiti Malaya, 59990 Kuala Lumpur, MALAYSIA. Abstract:Background: In Southeast Asia and many parts of the world, herbal products are increasingly used in parallel with modern medicine. Objective: This study aimed to investigate the effects of herbs commonly used in Southeast Asia on activity of cytochrome P450 2C8 (CYP2C8), an important human hepatic enzyme in drug metabolism. Materials and Methods: The selected herbs, such as Eurycoma longifolia Jack (ELJ), Labisia pumila (LP), Echinacea purpurea (EP), Andrographis paniculata (AP), and Ginkgo biloba (GB), were subjected to inhibition studies using an in vitro CYP2C8 activity marker, amodiaquine N‑desethylase assay. Inhibition parameters, inhibitory concentration 50% (IC50), and Ki values were determined to study the potency and mode of inhibition. Results: All herbs inhibited CYP2C8 with the following order of potency: LP > ELJ > GB > AP > EP. LP and ELJ inhibited potently at Ki’s of 2 and 4 times the Ki of quercetin, the positive control. The inhibition by LP was uncompetitive in nature as compared to competitive or mixed type inhibition observed with other herbs. GB exhibited moderate inhibitory effect at a Ki 6 times larger than quercetin Ki. AP and EP, on the other hand, showed only weak inhibition. Conclusion: The herbs we chose represented the more commonly used herbs in Southeast Asia where collision of tradition and modernization in healthcare, if not properly managed, may lead to therapeutic misadventures. We conclude that concurrent consumption of some herbs, in particular, LP and ELJ, may have relevance in drug‑herb interactions via CYP2C8 inhibition in vivo. Keywords:Cytochrome P450, Cytochrome P450 2C8, Drug‑herb interaction, InhibitionView:PDF (814.64 KB)" @default.
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• W2511589291 date "2016-01-01" @default.
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• W2511589291 title "Inhibition of human cytochrome p450 2c8-catalyzed amodiaquine n-desethylation: Effect of five traditionally and commonly used herbs" @default.
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• W2511589291 doi "https://doi.org/10.4103/0974-8490.188886" @default.
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