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- W2511595932 abstract "An 18-year-old male presents with fatigue, recent weight loss, blurred vision, intermittent diarrhea, and gastric cramping; clinical and laboratory examination led to a diagnosis of type I diabetes mellitus (type I DM). The etiology, presumptive risk factors, and pathogenesis of type I DM are reviewed, with a focus on the disease as a manifestation of a dysregulated immune response. Major lines of inquiry include the preferential differentiation of tolerogenic regulatory T cells in the gut-associated lymphoid tissue (GALT) in response to metabolites of the gut microbiota as well as ligand-activated transcription factor, aryl hydrocarbon receptor (AhR), and by histone deacetylase inhibitors. Additional immunomodulatory effects of vitamin D and the pathogenesis of ketoacidosis are discussed. Diagnostic criteria, current standards of care, and evidence for targeted nutrient supplementation are presented. Other autoimmune conditions that present with type I DM include celiac disease. The pathogenesis, clinical presentation, and diet modification strategies for this condition are examined." @default.
- W2511595932 created "2016-09-16" @default.
- W2511595932 creator A5010658031 @default.
- W2511595932 date "2017-01-01" @default.
- W2511595932 modified "2023-10-16" @default.
- W2511595932 title "Type I Diabetes and Celiac Disease" @default.
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- W2511595932 doi "https://doi.org/10.1016/b978-0-12-803013-4.00003-x" @default.
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