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- W2511634517 abstract "Hemecan serveHaemophilus influenzae asa sourceofbothessential porphyrin andiron. Inextracellular mammalian bodyfluids neither free hemenorfree ironisavailable, since they aretightly boundtohemopexin andtransferrin, respectively. SinceH.influenzae grows inthepresenceofiron-transferrin andhemehemopexin andisknowntoexpressasaturable receptor fortransferrin, we investigated theprocessbywhich this pathogen acquired hemefromhemopexin foruse as an iron source.Theability ofhumanandrabbit hemopexin todonate hemeas a sourceofirontoH.influenzae typebstrains was demonstrated byplate bioassays. Witha dotenzyme assaywithbiotinylated hemopexin as ligand, H.influenzae boundhemehemopexin andapo-hemopexin following growthiniron-restricted, butnotiniron-sufficient, medium. Competitive binding studies withheme-hemopexin andapo-hemopexin demonstrated saturability ofbinding. Neither heme,protoporphyrin IX,hemoglobin, nor transferrin blocked thebinding ofhemopexin towhole cells, demonstrating thespecificity ofbinding. Treatment ofwholeH.influenzae cells withtrypsin abolished binding. Takentogether, these observations suggest thatH.influenzae typebexpressesan outermembrane protein(s) whichactsas a receptor forhemopexin andwhichisregulated bytheavailability ofironinthe growthmedium.Iniron-restricted media, H.influenzae 706705andDL42didnotexpressthe100-kDa hemopexin-binding" @default.
- W2511634517 created "2016-09-16" @default.
- W2511634517 creator A5017730248 @default.
- W2511634517 date "1994-01-01" @default.
- W2511634517 modified "2023-09-24" @default.
- W2511634517 title "Identification andCharacterization ofan Iron-Regulated Hemopexin Receptor inHaemophilus influenzae Typeb" @default.
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- W2511634517 hasPublicationYear "1994" @default.
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