FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511657557> ?p ?o ?g. }

• W2511657557 endingPage "1406" @default.
• W2511657557 startingPage "1397" @default.
• W2511657557 abstract "Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPS-CMs) are promising candidates for cell therapy, drug screening, and developmental studies. It is known that iPS-CMs possess immature electrophysiological properties, but an exact characterization of their developmental stage and subtype differentiation is hampered by a lack of knowledge of electrophysiological properties of native CMs from different developmental stages and origins within the heart. Thus, we sought to systematically investigate action potential (AP) properties of native murine CMs and to establish a database that allows classification of stem cell-derived CMs. Hearts from 129S2PasCrl mice were harvested at days 9-10, 12-14, and 16-18 postcoitum, as well as 1 day, 3-4 days, 1-2 weeks, 3-4 weeks, and 6 weeks postpartum. AP recordings in left and right atria and at apical, medial, and basal left and right ventricles were performed with sharp glass microelectrodes. Measurements revealed significant changes in AP morphology during pre- and postnatal murine development and significant differences between atria and ventricles, enabling a classification of developmental stage and subtype differentiation of stem cell-derived CMs based on their AP properties. For iPS-CMs derived from cell line TiB7.4, a typical ventricular phenotype was demonstrated at later developmental stages, while there were electrophysiological differences from atrial as well as ventricular native CMs at earlier stages. This finding supports that iPS-CMs can develop AP properties similar to native CMs, but points to differences in the maturation process between iPS-CMs and native CMs, which may be explained by dissimilar conditions during in vitro differentiation and in vivo development." @default.
• W2511657557 created "2016-09-16" @default.
• W2511657557 creator A5000656991 @default.
• W2511657557 creator A5006334851 @default.
• W2511657557 creator A5008665339 @default.
• W2511657557 creator A5010161793 @default.
• W2511657557 creator A5039835530 @default.
• W2511657557 creator A5079453349 @default.
• W2511657557 creator A5083746732 @default.
• W2511657557 date "2016-10-01" @default.
• W2511657557 modified "2023-10-13" @default.
• W2511657557 title "From Early Embryonic to Adult Stage: Comparative Study of Action Potentials of Native and Pluripotent Stem Cell-Derived Cardiomyocytes" @default.
• W2511657557 cites W1976309047 @default.
• W2511657557 cites W1980384559 @default.
• W2511657557 cites W1988810266 @default.
• W2511657557 cites W1991125709 @default.
• W2511657557 cites W1999334551 @default.
• W2511657557 cites W1999874338 @default.
• W2511657557 cites W2002179012 @default.
• W2511657557 cites W2004672485 @default.
• W2511657557 cites W2005586092 @default.
• W2511657557 cites W2010031978 @default.
• W2511657557 cites W2024133736 @default.
• W2511657557 cites W2031725294 @default.
• W2511657557 cites W2033926629 @default.
• W2511657557 cites W2053911973 @default.
• W2511657557 cites W2058642135 @default.
• W2511657557 cites W2064124462 @default.
• W2511657557 cites W2076023125 @default.
• W2511657557 cites W2077636083 @default.
• W2511657557 cites W2080148146 @default.
• W2511657557 cites W2084889822 @default.
• W2511657557 cites W2086614611 @default.
• W2511657557 cites W2089627740 @default.
• W2511657557 cites W2090199635 @default.
• W2511657557 cites W2093540365 @default.
• W2511657557 cites W2098470464 @default.
• W2511657557 cites W2099474957 @default.
• W2511657557 cites W2107733633 @default.
• W2511657557 cites W2120429264 @default.
• W2511657557 cites W2121443870 @default.
• W2511657557 cites W2125987139 @default.
• W2511657557 cites W2128085444 @default.
• W2511657557 cites W2130390822 @default.
• W2511657557 cites W2130668754 @default.
• W2511657557 cites W2138977668 @default.
• W2511657557 cites W2142046859 @default.
• W2511657557 cites W2144950329 @default.
• W2511657557 cites W2145771428 @default.
• W2511657557 cites W2150048579 @default.
• W2511657557 cites W2157647701 @default.
• W2511657557 cites W2160165423 @default.
• W2511657557 cites W2168806904 @default.
• W2511657557 cites W2192043288 @default.
• W2511657557 cites W4246928383 @default.
• W2511657557 doi "https://doi.org/10.1089/scd.2016.0073" @default.
• W2511657557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27484788" @default.
• W2511657557 hasPublicationYear "2016" @default.
• W2511657557 type Work @default.
• W2511657557 sameAs 2511657557 @default.
• W2511657557 citedByCount "15" @default.
• W2511657557 countsByYear W25116575572017 @default.
• W2511657557 countsByYear W25116575572018 @default.
• W2511657557 countsByYear W25116575572019 @default.
• W2511657557 countsByYear W25116575572020 @default.
• W2511657557 countsByYear W25116575572021 @default.
• W2511657557 countsByYear W25116575572022 @default.
• W2511657557 countsByYear W25116575572023 @default.
• W2511657557 crossrefType "journal-article" @default.
• W2511657557 hasAuthorship W2511657557A5000656991 @default.
• W2511657557 hasAuthorship W2511657557A5006334851 @default.
• W2511657557 hasAuthorship W2511657557A5008665339 @default.
• W2511657557 hasAuthorship W2511657557A5010161793 @default.
• W2511657557 hasAuthorship W2511657557A5039835530 @default.
• W2511657557 hasAuthorship W2511657557A5079453349 @default.
• W2511657557 hasAuthorship W2511657557A5083746732 @default.
• W2511657557 hasConcept C104317684 @default.
• W2511657557 hasConcept C105702510 @default.
• W2511657557 hasConcept C107459253 @default.
• W2511657557 hasConcept C10854531 @default.
• W2511657557 hasConcept C145103041 @default.
• W2511657557 hasConcept C148738053 @default.
• W2511657557 hasConcept C1491633281 @default.
• W2511657557 hasConcept C169760540 @default.
• W2511657557 hasConcept C183074962 @default.
• W2511657557 hasConcept C185263204 @default.
• W2511657557 hasConcept C28328180 @default.
• W2511657557 hasConcept C54355233 @default.
• W2511657557 hasConcept C86803240 @default.
• W2511657557 hasConcept C95444343 @default.
• W2511657557 hasConceptScore W2511657557C104317684 @default.
• W2511657557 hasConceptScore W2511657557C105702510 @default.
• W2511657557 hasConceptScore W2511657557C107459253 @default.
• W2511657557 hasConceptScore W2511657557C10854531 @default.
• W2511657557 hasConceptScore W2511657557C145103041 @default.
• W2511657557 hasConceptScore W2511657557C148738053 @default.
• W2511657557 hasConceptScore W2511657557C1491633281 @default.
• W2511657557 hasConceptScore W2511657557C169760540 @default.

• next