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- W2511668879 abstract "An increasingly popular absolute quantitative technique involves the SRM or MRM approach with stable isotope-labeled standards (SIS). Using this approach, many proteins in human plasma/serum have been quantified for biomarker assessment and disease stratification. Due to the complexity of plasma and the invasive nature of its collection, alternative biosamples are currently being explored. Here, we present the broadest panel of multiplexed MRM assays with SIS peptides for saliva proteins developed to date. The validated panel consists of 158 candidate human saliva protein biomarkers, inferred from 244 interference-free peptides. The resulting concentrations were reproducibly quantified over a 6 order-of-magnitude concentration range (from 218 μg/mL to 88 pg/mL; average CVs of 12% over analytical triplicates). All concentrations were determined from reverse standard curves, which were generated using a constant concentration of endogenous material with varying concentrations of spiked-in SIS peptides. The large-scale screening of the soluble and membrane-associated proteins contained within the 158-plex assay could present new opportunities for biomarker assessment and clinical diagnostics." @default.
- W2511668879 created "2016-09-16" @default.
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- W2511668879 date "2016-10-19" @default.
- W2511668879 modified "2023-10-17" @default.
- W2511668879 title "Multiplexed panel of precisely quantified salivary proteins for biomarker assessment" @default.
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- W2511668879 doi "https://doi.org/10.1002/pmic.201600230" @default.
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