FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511690506> ?p ?o ?g. }

• W2511690506 abstract "Abstract Protein tyrosine phosphorylation is an important mechanism that regulates cytoskeleton reorganization and cell spreading of migratory cells. A number of cytoskeletal proteins are known to be tyrosine phosphorylated (pY) in different cellular processes. However, the profile of pY proteins during different stages of cell spreading has not been available. Using immunoafffinity enrichment of pY proteins coupled with label free quantitative proteomics, we quantitatively identified 447 pY proteins in the migratory ECV-304 cells at the early spreading (adhesion) and the active spreading stages. We found that pY levels of the majority of the quantified proteins were significantly increased in the active spreading stage compared with the early spreading stage, suggesting that active cell spreading is concomitant with extra tyrosine phosphorylation. The major categories of proteins impacted by tyrosine phosphorylation are involved in cytoskeleton and focal adhesion regulation, protein translation and degradation. Our findings, for the first time, dissect the cell spreading-specific pY signals from the adhesion induced pY signals and provide a valuable resource for the future mechanistic research regarding the regulation of cell spreading." @default.
• W2511690506 created "2016-09-16" @default.
• W2511690506 creator A5002747282 @default.
• W2511690506 creator A5006787895 @default.
• W2511690506 creator A5014664356 @default.
• W2511690506 creator A5020478268 @default.
• W2511690506 creator A5023583600 @default.
• W2511690506 creator A5057712848 @default.
• W2511690506 creator A5060070085 @default.
• W2511690506 creator A5074366934 @default.
• W2511690506 date "2016-08-24" @default.
• W2511690506 modified "2023-09-25" @default.
• W2511690506 title "Quantitative profiling of spreading-coupled protein tyrosine phosphorylation in migratory cells" @default.
• W2511690506 cites W1484094963 @default.
• W2511690506 cites W1546173464 @default.
• W2511690506 cites W1969342647 @default.
• W2511690506 cites W1976716342 @default.
• W2511690506 cites W1982149350 @default.
• W2511690506 cites W1989686918 @default.
• W2511690506 cites W1993410470 @default.
• W2511690506 cites W1994825452 @default.
• W2511690506 cites W2007876874 @default.
• W2511690506 cites W2017233644 @default.
• W2511690506 cites W2048209624 @default.
• W2511690506 cites W2057209737 @default.
• W2511690506 cites W2062706926 @default.
• W2511690506 cites W2067638924 @default.
• W2511690506 cites W2071199281 @default.
• W2511690506 cites W2076123445 @default.
• W2511690506 cites W2080752012 @default.
• W2511690506 cites W2091787667 @default.
• W2511690506 cites W2105356859 @default.
• W2511690506 cites W2111859893 @default.
• W2511690506 cites W2116130782 @default.
• W2511690506 cites W2117040422 @default.
• W2511690506 cites W2135523806 @default.
• W2511690506 cites W2135581618 @default.
• W2511690506 cites W2139130671 @default.
• W2511690506 cites W2152396103 @default.
• W2511690506 cites W2153920513 @default.
• W2511690506 cites W2155293713 @default.
• W2511690506 cites W2157658519 @default.
• W2511690506 cites W2165923048 @default.
• W2511690506 cites W2166779196 @default.
• W2511690506 cites W2170776626 @default.
• W2511690506 cites W2236738108 @default.
• W2511690506 doi "https://doi.org/10.1038/srep31811" @default.
• W2511690506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4995472" @default.
• W2511690506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27554326" @default.
• W2511690506 hasPublicationYear "2016" @default.
• W2511690506 type Work @default.
• W2511690506 sameAs 2511690506 @default.
• W2511690506 citedByCount "6" @default.
• W2511690506 countsByYear W25116905062019 @default.
• W2511690506 countsByYear W25116905062020 @default.
• W2511690506 countsByYear W25116905062021 @default.
• W2511690506 countsByYear W25116905062023 @default.
• W2511690506 crossrefType "journal-article" @default.
• W2511690506 hasAuthorship W2511690506A5002747282 @default.
• W2511690506 hasAuthorship W2511690506A5006787895 @default.
• W2511690506 hasAuthorship W2511690506A5014664356 @default.
• W2511690506 hasAuthorship W2511690506A5020478268 @default.
• W2511690506 hasAuthorship W2511690506A5023583600 @default.
• W2511690506 hasAuthorship W2511690506A5057712848 @default.
• W2511690506 hasAuthorship W2511690506A5060070085 @default.
• W2511690506 hasAuthorship W2511690506A5074366934 @default.
• W2511690506 hasBestOaLocation W25116905061 @default.
• W2511690506 hasConcept C104317684 @default.
• W2511690506 hasConcept C11960822 @default.
• W2511690506 hasConcept C142669718 @default.
• W2511690506 hasConcept C1491633281 @default.
• W2511690506 hasConcept C151166631 @default.
• W2511690506 hasConcept C185592680 @default.
• W2511690506 hasConcept C2776165026 @default.
• W2511690506 hasConcept C2777553839 @default.
• W2511690506 hasConcept C46111723 @default.
• W2511690506 hasConcept C55493867 @default.
• W2511690506 hasConcept C85789140 @default.
• W2511690506 hasConcept C86803240 @default.
• W2511690506 hasConcept C87325107 @default.
• W2511690506 hasConcept C95444343 @default.
• W2511690506 hasConcept C97029542 @default.
• W2511690506 hasConceptScore W2511690506C104317684 @default.
• W2511690506 hasConceptScore W2511690506C11960822 @default.
• W2511690506 hasConceptScore W2511690506C142669718 @default.
• W2511690506 hasConceptScore W2511690506C1491633281 @default.
• W2511690506 hasConceptScore W2511690506C151166631 @default.
• W2511690506 hasConceptScore W2511690506C185592680 @default.
• W2511690506 hasConceptScore W2511690506C2776165026 @default.
• W2511690506 hasConceptScore W2511690506C2777553839 @default.
• W2511690506 hasConceptScore W2511690506C46111723 @default.
• W2511690506 hasConceptScore W2511690506C55493867 @default.
• W2511690506 hasConceptScore W2511690506C85789140 @default.
• W2511690506 hasConceptScore W2511690506C86803240 @default.
• W2511690506 hasConceptScore W2511690506C87325107 @default.
• W2511690506 hasConceptScore W2511690506C95444343 @default.
• W2511690506 hasConceptScore W2511690506C97029542 @default.
• W2511690506 hasIssue "1" @default.
• W2511690506 hasLocation W25116905061 @default.
• W2511690506 hasLocation W25116905062 @default.

• next