FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511753822> ?p ?o ?g. }

• W2511753822 endingPage "852" @default.
• W2511753822 startingPage "839" @default.
• W2511753822 abstract "Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback is well known, the positive feedback control for augmenting VEGF signaling remains poorly understood. Transcription factor Sox17 is indispensable for angiogenesis, but its association with VEGF signaling is largely unknown. The contribution of other Sox members to angiogenesis also remains to be determined.To reveal the genetic interaction of Sox7, another Sox member, with Sox17 in developmental angiogenesis and their functional relationship with VEGF signaling.Sox7 is expressed specifically in endothelial cells and its global and endothelial-specific deletion resulted in embryonic lethality with severely impaired angiogenesis in mice, substantially overlapping with Sox17 in both expression and function. Interestingly, compound heterozygosity for Sox7 and Sox17 phenocopied vascular defects of Sox7 or Sox17 homozygous knockout, indicating that the genetic cooperation of Sox7 and Sox17 is sensitive to their combined gene dosage. VEGF signaling upregulated both Sox7 and Sox17 expression in angiogenesis via mTOR pathway. Furthermore, Sox7 and Sox17 promoted VEGFR2 (VEGF receptor 2) expression in angiogenic vessels, suggesting a positive feedback loop between VEGF signaling and SoxF.Our findings demonstrate that SoxF transcription factors are indispensable players in developmental angiogenesis by acting as positive feedback regulators of VEGF signaling." @default.
• W2511753822 created "2016-09-16" @default.
• W2511753822 creator A5012204048 @default.
• W2511753822 creator A5014051786 @default.
• W2511753822 creator A5027410859 @default.
• W2511753822 creator A5031241864 @default.
• W2511753822 creator A5033943394 @default.
• W2511753822 creator A5034021674 @default.
• W2511753822 creator A5039887705 @default.
• W2511753822 creator A5040675340 @default.
• W2511753822 creator A5047199948 @default.
• W2511753822 creator A5055571692 @default.
• W2511753822 creator A5056733357 @default.
• W2511753822 creator A5061682089 @default.
• W2511753822 creator A5090595716 @default.
• W2511753822 date "2016-09-16" @default.
• W2511753822 modified "2023-10-13" @default.
• W2511753822 title "SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling" @default.
• W2511753822 cites W1964018614 @default.
• W2511753822 cites W1966018836 @default.
• W2511753822 cites W1966140594 @default.
• W2511753822 cites W1970338125 @default.
• W2511753822 cites W1971162717 @default.
• W2511753822 cites W1974365957 @default.
• W2511753822 cites W1979251800 @default.
• W2511753822 cites W1982219839 @default.
• W2511753822 cites W1988850210 @default.
• W2511753822 cites W1994028945 @default.
• W2511753822 cites W2005797070 @default.
• W2511753822 cites W2013410789 @default.
• W2511753822 cites W2023189883 @default.
• W2511753822 cites W2024424388 @default.
• W2511753822 cites W2029372290 @default.
• W2511753822 cites W2031683488 @default.
• W2511753822 cites W2047984489 @default.
• W2511753822 cites W2056326894 @default.
• W2511753822 cites W2062240872 @default.
• W2511753822 cites W2070939204 @default.
• W2511753822 cites W2073303427 @default.
• W2511753822 cites W2073551059 @default.
• W2511753822 cites W2080154785 @default.
• W2511753822 cites W2081242900 @default.
• W2511753822 cites W2089091860 @default.
• W2511753822 cites W2104918009 @default.
• W2511753822 cites W2109418446 @default.
• W2511753822 cites W2111955151 @default.
• W2511753822 cites W2114662093 @default.
• W2511753822 cites W2118072878 @default.
• W2511753822 cites W2131463364 @default.
• W2511753822 cites W2131515610 @default.
• W2511753822 cites W2133159319 @default.
• W2511753822 cites W2136272779 @default.
• W2511753822 cites W2140251888 @default.
• W2511753822 cites W2147871659 @default.
• W2511753822 cites W2147934804 @default.
• W2511753822 cites W2148129201 @default.
• W2511753822 cites W2152278958 @default.
• W2511753822 cites W2160994463 @default.
• W2511753822 cites W2260982041 @default.
• W2511753822 doi "https://doi.org/10.1161/circresaha.116.308483" @default.
• W2511753822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27528602" @default.
• W2511753822 hasPublicationYear "2016" @default.
• W2511753822 type Work @default.
• W2511753822 sameAs 2511753822 @default.
• W2511753822 citedByCount "56" @default.
• W2511753822 countsByYear W25117538222017 @default.
• W2511753822 countsByYear W25117538222018 @default.
• W2511753822 countsByYear W25117538222019 @default.
• W2511753822 countsByYear W25117538222020 @default.
• W2511753822 countsByYear W25117538222021 @default.
• W2511753822 countsByYear W25117538222022 @default.
• W2511753822 countsByYear W25117538222023 @default.
• W2511753822 crossrefType "journal-article" @default.
• W2511753822 hasAuthorship W2511753822A5012204048 @default.
• W2511753822 hasAuthorship W2511753822A5014051786 @default.
• W2511753822 hasAuthorship W2511753822A5027410859 @default.
• W2511753822 hasAuthorship W2511753822A5031241864 @default.
• W2511753822 hasAuthorship W2511753822A5033943394 @default.
• W2511753822 hasAuthorship W2511753822A5034021674 @default.
• W2511753822 hasAuthorship W2511753822A5039887705 @default.
• W2511753822 hasAuthorship W2511753822A5040675340 @default.
• W2511753822 hasAuthorship W2511753822A5047199948 @default.
• W2511753822 hasAuthorship W2511753822A5055571692 @default.
• W2511753822 hasAuthorship W2511753822A5056733357 @default.
• W2511753822 hasAuthorship W2511753822A5061682089 @default.
• W2511753822 hasAuthorship W2511753822A5090595716 @default.
• W2511753822 hasBestOaLocation W25117538221 @default.
• W2511753822 hasConcept C104317684 @default.
• W2511753822 hasConcept C145103041 @default.
• W2511753822 hasConcept C161879069 @default.
• W2511753822 hasConcept C167734588 @default.
• W2511753822 hasConcept C2777025900 @default.
• W2511753822 hasConcept C2780394083 @default.
• W2511753822 hasConcept C502942594 @default.
• W2511753822 hasConcept C54355233 @default.
• W2511753822 hasConcept C62478195 @default.
• W2511753822 hasConcept C86339819 @default.
• W2511753822 hasConcept C86803240 @default.

• next