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- W2511760087 abstract "Administration to anaesthetized rats of N- methyl-D-aspartate (NMDA 30 nmol ICV) induced a pro- found derangement of stimulation evoked potential (f-SEP) and also autonomic excitation with an increase in arterial blood pressure and heart rate. These effects were antagonised by pretreatment with dizocilpine (0.5 mg/kg IV). Pretreatment with chlormethiazole (20 mg/kg IV 26 rain before NMDA) also markedly diminished the derangement of f-SEP. At the end of the registration period 2 h after NMDA the SEP had recovered to 72.7 + 3A (% of control; mean + SEM) in saline-treated rats as compared to 96.1 +_ 5.6% in chlormethiazote treated animals (P < 0.01). In contrast to dizocilpine, chlormeth- iazote alone had no effect on heart rate or blood pressure and did not alter the autonomic effects of ICV NMDA. These results demonstrate that chlormethiazole can ant- agonise some NMDA-receptor mediated functions, even though there is no evidence that it is an NMDA antag-" @default.
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- W2511760087 date "1993-01-01" @default.
- W2511760087 modified "2023-10-01" @default.
- W2511760087 title "Rapid communication Chlormethiazole attenuates the derangement of sensory evoked potential (SEP) induced by ICV administration of NMDA" @default.
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