Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511767035> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2511767035 abstract "Background: Abnormal cholesterol homeostasis is associated with the pathogenesis of neurodegenerative disease and cognitive impairment. Objectives: Our objective was to evaluate changes in the expression of proteins related to cognition and cholesterol homeostasis in the hippocampi of rats as well as behavioral modifications following the administration of a cholesterol-rich diet. Methods: In this experimental study, lasting 16 weeks, 20 male Wistar rats (aged 8 weeks) were randomly divided into two groups. One group was fed with a normal diet (ND; n = 10) and the second with a high cholesterol diet (HD; n = 10). The expression of the cognition-related proteins N-methyl-D-aspartate receptor (NMDAR) and beta-secretase 1 (BACE1) and cholesterol 24-hydroxylase (CYP46A1), the key cholesterol hemostasis protein, were determined by an immunoblotting assay in the hippocampus homogenate. The Morris water maze (MWM) test was used to examine cognitive performance. Plasma lipidic parameters, including total choles- terol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG), as well as brain TC were measured by colorimetric assay. Results: After a high cholesterol diet had been administered for a period of 16 weeks, a significant increase in TC, LDL-C and TG was observed in the HD group in comparison with the ND group (P < 0.05). Neither the mean of brain wet weight nor brain TC showed significant change in the HD versus the ND group (P = 0.114, P = 0.84, respectively). Despite this fixity, dierences in the expression of BACE1 and CYP46A1 were significant (P < 0.05) between the two groups, with high levels of BACE1 and CYP46A1 in the HD group compared with the ND group. These biochemical changes were associated with a significant decrease in the time traveled on a platform quadrant in the HD versus the ND group (P < 0.05) during a spatial memory probe test administered at the same time. Conclusions: The findings show that irregularities in cognitive performance as a result of a high cholesterol diet can be partially mediated by distortion in brain cholesterol homeostasis and processing of the amyloid precursor protein (APP)." @default.
- W2511767035 created "2016-09-16" @default.
- W2511767035 creator A5003172116 @default.
- W2511767035 creator A5009669912 @default.
- W2511767035 creator A5054634358 @default.
- W2511767035 creator A5066244929 @default.
- W2511767035 creator A5070130809 @default.
- W2511767035 creator A5083725557 @default.
- W2511767035 date "2016-08-30" @default.
- W2511767035 modified "2023-09-25" @default.
- W2511767035 title "High Cholesterol Diet Increases Expression of Cholesterol 24-Hydroxylase and BACE1 in Rat Hippocampi: Implications for the Effect of Diet Cholesterol on Memory" @default.
- W2511767035 cites W1136751452 @default.
- W2511767035 cites W1663125803 @default.
- W2511767035 cites W1824457652 @default.
- W2511767035 cites W1899889838 @default.
- W2511767035 cites W1972579135 @default.
- W2511767035 cites W1979477650 @default.
- W2511767035 cites W1985288309 @default.
- W2511767035 cites W1986305892 @default.
- W2511767035 cites W1992465104 @default.
- W2511767035 cites W2014241684 @default.
- W2511767035 cites W2016512153 @default.
- W2511767035 cites W2018952034 @default.
- W2511767035 cites W2048397840 @default.
- W2511767035 cites W2049909198 @default.
- W2511767035 cites W2052659964 @default.
- W2511767035 cites W2056810885 @default.
- W2511767035 cites W2064072223 @default.
- W2511767035 cites W2067697619 @default.
- W2511767035 cites W2073741367 @default.
- W2511767035 cites W2077966741 @default.
- W2511767035 cites W2080063671 @default.
- W2511767035 cites W2081713863 @default.
- W2511767035 cites W2084399812 @default.
- W2511767035 cites W2090253176 @default.
- W2511767035 cites W2101169038 @default.
- W2511767035 cites W2109830759 @default.
- W2511767035 cites W2117842413 @default.
- W2511767035 cites W2130768675 @default.
- W2511767035 cites W2131963133 @default.
- W2511767035 cites W2132212053 @default.
- W2511767035 cites W2187014633 @default.
- W2511767035 cites W2201198379 @default.
- W2511767035 cites W2234325697 @default.
- W2511767035 cites W2238869079 @default.
- W2511767035 cites W2284289392 @default.
- W2511767035 cites W2325767759 @default.
- W2511767035 cites W2330756578 @default.
- W2511767035 cites W839903919 @default.
- W2511767035 doi "https://doi.org/10.5812/ircmj.35677" @default.
- W2511767035 hasPublicationYear "2016" @default.
- W2511767035 type Work @default.
- W2511767035 sameAs 2511767035 @default.
- W2511767035 citedByCount "4" @default.
- W2511767035 countsByYear W25117670352019 @default.
- W2511767035 countsByYear W25117670352021 @default.
- W2511767035 countsByYear W25117670352023 @default.
- W2511767035 crossrefType "journal-article" @default.
- W2511767035 hasAuthorship W2511767035A5003172116 @default.
- W2511767035 hasAuthorship W2511767035A5009669912 @default.
- W2511767035 hasAuthorship W2511767035A5054634358 @default.
- W2511767035 hasAuthorship W2511767035A5066244929 @default.
- W2511767035 hasAuthorship W2511767035A5070130809 @default.
- W2511767035 hasAuthorship W2511767035A5083725557 @default.
- W2511767035 hasConcept C126322002 @default.
- W2511767035 hasConcept C134018914 @default.
- W2511767035 hasConcept C2778163477 @default.
- W2511767035 hasConcept C2779073485 @default.
- W2511767035 hasConcept C2779965577 @default.
- W2511767035 hasConcept C71924100 @default.
- W2511767035 hasConceptScore W2511767035C126322002 @default.
- W2511767035 hasConceptScore W2511767035C134018914 @default.
- W2511767035 hasConceptScore W2511767035C2778163477 @default.
- W2511767035 hasConceptScore W2511767035C2779073485 @default.
- W2511767035 hasConceptScore W2511767035C2779965577 @default.
- W2511767035 hasConceptScore W2511767035C71924100 @default.
- W2511767035 hasIssue "12" @default.
- W2511767035 hasLocation W25117670351 @default.
- W2511767035 hasOpenAccess W2511767035 @default.
- W2511767035 hasPrimaryLocation W25117670351 @default.
- W2511767035 hasRelatedWork W1966504330 @default.
- W2511767035 hasRelatedWork W1966775726 @default.
- W2511767035 hasRelatedWork W1979139803 @default.
- W2511767035 hasRelatedWork W2030889776 @default.
- W2511767035 hasRelatedWork W2035331946 @default.
- W2511767035 hasRelatedWork W2037631372 @default.
- W2511767035 hasRelatedWork W2040058909 @default.
- W2511767035 hasRelatedWork W2132898409 @default.
- W2511767035 hasRelatedWork W2748952813 @default.
- W2511767035 hasRelatedWork W4249176446 @default.
- W2511767035 hasVolume "18" @default.
- W2511767035 isParatext "false" @default.
- W2511767035 isRetracted "false" @default.
- W2511767035 magId "2511767035" @default.
- W2511767035 workType "article" @default.