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- W2511792204 abstract "Genus Scutellaria (Lamiaceae), is widespread in all over the world, has 25 taxa in Turkey. Among them 14 taxa are endemic [1,2]. Scutellaria species and their active principles possess antitumor, anti-angiogenesis, hepatoprotective, antioxidant, anticonvulsant, antibacterial, and antiviral activities [1]. In this study, endemic S. salviifolia aqueous extract is evaluated for its liver X receptors (LXRs) ligand activity using a LXRα luciferase reporter assay, antioxidant activity on DPPH, NO, SO radicals and cytotoxic activity against HEp-2 cell line. LXRs play role in de novo synthesis of cholesterol, excretion and detoxification of bile acids, or lipids, glucose homeostasis, neurological functions and inflammation. Recent discoveries found LXRs could regulate tumor growth in a variety of cancer cell lines [3]. Since the extract showed potent LXRα agonistic activity, it was subjected to polyamide column for fractionation of active compounds. The extract and fractions were tested for their antioxidant and cytotoxic activities. Flavonoid-rich fractions (Frs. D-E) were found to be the most active fractions in the both test systems. IC50 values of Frs. D-E were determined as 116 and 33 µg/mL for cytotoxic and 20 – 202 µg/mL for antioxidant activities, respectively. The active fractions were applied to serial column chromatografies to give compounds 1 (apigenin), 2 (luteolin-7-O-β-glucopyranoside) and 3 (apigenin-7-O-β-glucopyranoside) in pure form. Studies on active constituents are still in progress." @default.
- W2511792204 created "2016-09-16" @default.
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- W2511792204 date "2015-11-25" @default.
- W2511792204 modified "2023-09-26" @default.
- W2511792204 title "Bioactivity based phytochemical studies on Scutellaria salviifolia Benth." @default.
- W2511792204 doi "https://doi.org/10.1055/s-0035-1565455" @default.
- W2511792204 hasPublicationYear "2015" @default.
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