FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511821457> ?p ?o ?g. }

• W2511821457 endingPage "11801" @default.
• W2511821457 startingPage "11792" @default.
• W2511821457 abstract "Despite its important role in biology and nanotechnology, many questions remain regarding the molecular mechanism and dynamics by which oligonucleotides recognize and hybridize to their complementary sequence. The thermodynamics and kinetics of DNA oligonucleotide hybridization and dehybridization are often assumed to involve an all-or-nothing two-state dissociation pathway, but deviations from this behavior can be considerable even for short sequences. We introduce a new strategy to characterize the base-pair-specific thermal dissociation mechanism of DNA oligonucleotides through steady-state and time-resolved infrared spectroscopy. Experiments are interpreted with a lattice model to provide a structure-specific interpretation. This method is applied to a model set of self-complementary 10-base-pair sequences in which the placement of GC base pairs is varied in an otherwise AT strand. Through a combination of Fourier transform infrared and two-dimensional infrared spectroscopy, experiments reveal varying degrees of deviation from simple two-state behavior. As the temperature is increased, duplexes dissociate through a path in which the terminal bases fray, without any significant contribution from loop configurations. Transient temperature jump experiments reveal time scales of 70–100 ns for fraying and 10–30 μs for complete dissociation near the melting temperature. Whether or not frayed states are metastable intermediates or short-lived configurations during the full dissociation of the duplex is dictated by the nucleobase sequence." @default.
• W2511821457 created "2016-09-16" @default.
• W2511821457 creator A5021659494 @default.
• W2511821457 creator A5032296072 @default.
• W2511821457 creator A5048394952 @default.
• W2511821457 date "2016-08-31" @default.
• W2511821457 modified "2023-10-16" @default.
• W2511821457 title "Sequence-Dependent Mechanism of DNA Oligonucleotide Dehybridization Resolved through Infrared Spectroscopy" @default.
• W2511821457 cites W1969198420 @default.
• W2511821457 cites W1970205873 @default.
• W2511821457 cites W1970663985 @default.
• W2511821457 cites W1972708527 @default.
• W2511821457 cites W1975335922 @default.
• W2511821457 cites W1978084642 @default.
• W2511821457 cites W1983869679 @default.
• W2511821457 cites W1988753748 @default.
• W2511821457 cites W1991089533 @default.
• W2511821457 cites W1991198187 @default.
• W2511821457 cites W1991933856 @default.
• W2511821457 cites W2001001471 @default.
• W2511821457 cites W2004361937 @default.
• W2511821457 cites W2009095852 @default.
• W2511821457 cites W2009773926 @default.
• W2511821457 cites W2016638271 @default.
• W2511821457 cites W2017635466 @default.
• W2511821457 cites W2026346625 @default.
• W2511821457 cites W2030261975 @default.
• W2511821457 cites W2030303368 @default.
• W2511821457 cites W2031585184 @default.
• W2511821457 cites W2035485234 @default.
• W2511821457 cites W2039920077 @default.
• W2511821457 cites W2042190518 @default.
• W2511821457 cites W2044112600 @default.
• W2511821457 cites W2045533286 @default.
• W2511821457 cites W2051753857 @default.
• W2511821457 cites W2062999326 @default.
• W2511821457 cites W2073273766 @default.
• W2511821457 cites W2084868118 @default.
• W2511821457 cites W2087117796 @default.
• W2511821457 cites W2090604290 @default.
• W2511821457 cites W2094804945 @default.
• W2511821457 cites W2096295791 @default.
• W2511821457 cites W2106130068 @default.
• W2511821457 cites W2109887615 @default.
• W2511821457 cites W2116415905 @default.
• W2511821457 cites W2118209972 @default.
• W2511821457 cites W2127753323 @default.
• W2511821457 cites W2128014753 @default.
• W2511821457 cites W2135995702 @default.
• W2511821457 cites W2138028869 @default.
• W2511821457 cites W2138851678 @default.
• W2511821457 cites W2146855073 @default.
• W2511821457 cites W2148101811 @default.
• W2511821457 cites W2148602202 @default.
• W2511821457 cites W2155544170 @default.
• W2511821457 cites W2158818321 @default.
• W2511821457 cites W2162691613 @default.
• W2511821457 cites W2246141446 @default.
• W2511821457 cites W2293363147 @default.
• W2511821457 cites W2321603593 @default.
• W2511821457 cites W3103586898 @default.
• W2511821457 cites W3105782922 @default.
• W2511821457 doi "https://doi.org/10.1021/jacs.6b05854" @default.
• W2511821457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27519555" @default.
• W2511821457 hasPublicationYear "2016" @default.
• W2511821457 type Work @default.
• W2511821457 sameAs 2511821457 @default.
• W2511821457 citedByCount "54" @default.
• W2511821457 countsByYear W25118214572016 @default.
• W2511821457 countsByYear W25118214572017 @default.
• W2511821457 countsByYear W25118214572018 @default.
• W2511821457 countsByYear W25118214572019 @default.
• W2511821457 countsByYear W25118214572020 @default.
• W2511821457 countsByYear W25118214572021 @default.
• W2511821457 countsByYear W25118214572022 @default.
• W2511821457 countsByYear W25118214572023 @default.
• W2511821457 crossrefType "journal-article" @default.
• W2511821457 hasAuthorship W2511821457A5021659494 @default.
• W2511821457 hasAuthorship W2511821457A5032296072 @default.
• W2511821457 hasAuthorship W2511821457A5048394952 @default.
• W2511821457 hasConcept C102931765 @default.
• W2511821457 hasConcept C120665830 @default.
• W2511821457 hasConcept C121332964 @default.
• W2511821457 hasConcept C129312508 @default.
• W2511821457 hasConcept C147789679 @default.
• W2511821457 hasConcept C153642686 @default.
• W2511821457 hasConcept C158355884 @default.
• W2511821457 hasConcept C159467904 @default.
• W2511821457 hasConcept C178790620 @default.
• W2511821457 hasConcept C185581394 @default.
• W2511821457 hasConcept C185592680 @default.
• W2511821457 hasConcept C191961535 @default.
• W2511821457 hasConcept C32891209 @default.
• W2511821457 hasConcept C552990157 @default.
• W2511821457 hasConcept C55493867 @default.
• W2511821457 hasConcept C61234307 @default.
• W2511821457 hasConcept C62520636 @default.
• W2511821457 hasConcept C65550862 @default.

• next