FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511831439> ?p ?o ?g. }

• W2511831439 endingPage "7" @default.
• W2511831439 startingPage "1" @default.
• W2511831439 abstract "Spray-freeze-dried powders were suggested for nasal, epidermal (needle-free injection) or pulmonary application of proteins, peptides or nucleic acids. In spray-freeze-drying processes an aqueous solution is atomized into a refrigerant medium and subsequently dried by sublimation. Droplet-stream generators produce a fast stream of monodisperse droplets, where droplets are subject to collisions and therefore the initial monodispersity is lost and droplets increase in diameter, which reduces their suitability for pulmonary application. In jet-vortex-freezing, a droplet-stream is injected into a vortex of cold process gas to prevent droplet collisions. Both the injection position of the droplet-stream and the velocity of the cold gas vortex have an impact on the size distributions of the resulting powders. A model solution containing mannitol (1.5%m/V) and maltodextrin (1.5%m/V) was sprayed at 5 droplet-stream positions at distances between 1mm and 30mm from the gas jet nozzle and 5 gas velocities (0.8-6.8m/s) at a process temperature of -100°C. Mean geometric diameters of the highly porous particles (bulk density: 0.012±0.007g/cm3) ranged between 55±4 and 98±4μm. Evaluation of the aerodynamic properties by Next-Generation-Impactor (NGI) analysis showed that all powders had high emitted doses (98±1%) and fine-particle fractions ranged between 4±1% and 21±2%. It was shown that jet-vortex freezing is a suitable method for the reproducible production of lyophilized powders with excellent dispersibility in air, which has a high potential for nasal and pulmonary drug delivery." @default.
• W2511831439 created "2016-09-16" @default.
• W2511831439 creator A5013955075 @default.
• W2511831439 creator A5031084641 @default.
• W2511831439 creator A5087419324 @default.
• W2511831439 date "2017-01-01" @default.
• W2511831439 modified "2023-10-14" @default.
• W2511831439 title "Jet-vortex spray freeze drying for the production of inhalable lyophilisate powders" @default.
• W2511831439 cites W1508056905 @default.
• W2511831439 cites W178161124 @default.
• W2511831439 cites W1965787425 @default.
• W2511831439 cites W1972156427 @default.
• W2511831439 cites W1980803266 @default.
• W2511831439 cites W1982285805 @default.
• W2511831439 cites W1993548548 @default.
• W2511831439 cites W1997101791 @default.
• W2511831439 cites W2040157366 @default.
• W2511831439 cites W2046080776 @default.
• W2511831439 cites W2054616259 @default.
• W2511831439 cites W2067595625 @default.
• W2511831439 cites W2078036942 @default.
• W2511831439 cites W2082612497 @default.
• W2511831439 cites W2086205802 @default.
• W2511831439 cites W2088436358 @default.
• W2511831439 cites W2092208606 @default.
• W2511831439 cites W2104000547 @default.
• W2511831439 cites W2113278548 @default.
• W2511831439 cites W2132740239 @default.
• W2511831439 cites W2146957723 @default.
• W2511831439 cites W2154586352 @default.
• W2511831439 cites W2164698838 @default.
• W2511831439 cites W2170264619 @default.
• W2511831439 cites W2174826642 @default.
• W2511831439 cites W2274701398 @default.
• W2511831439 cites W2288962493 @default.
• W2511831439 cites W312820303 @default.
• W2511831439 doi "https://doi.org/10.1016/j.ejps.2016.08.062" @default.
• W2511831439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27593988" @default.
• W2511831439 hasPublicationYear "2017" @default.
• W2511831439 type Work @default.
• W2511831439 sameAs 2511831439 @default.
• W2511831439 citedByCount "15" @default.
• W2511831439 countsByYear W25118314392018 @default.
• W2511831439 countsByYear W25118314392019 @default.
• W2511831439 countsByYear W25118314392020 @default.
• W2511831439 countsByYear W25118314392021 @default.
• W2511831439 countsByYear W25118314392022 @default.
• W2511831439 crossrefType "journal-article" @default.
• W2511831439 hasAuthorship W2511831439A5013955075 @default.
• W2511831439 hasAuthorship W2511831439A5031084641 @default.
• W2511831439 hasAuthorship W2511831439A5087419324 @default.
• W2511831439 hasConcept C113196181 @default.
• W2511831439 hasConcept C11432220 @default.
• W2511831439 hasConcept C119947313 @default.
• W2511831439 hasConcept C121332964 @default.
• W2511831439 hasConcept C127413603 @default.
• W2511831439 hasConcept C140820882 @default.
• W2511831439 hasConcept C147789679 @default.
• W2511831439 hasConcept C15744967 @default.
• W2511831439 hasConcept C184651966 @default.
• W2511831439 hasConcept C185592680 @default.
• W2511831439 hasConcept C188027245 @default.
• W2511831439 hasConcept C192562407 @default.
• W2511831439 hasConcept C2779587474 @default.
• W2511831439 hasConcept C42360764 @default.
• W2511831439 hasConcept C43617362 @default.
• W2511831439 hasConcept C542102704 @default.
• W2511831439 hasConcept C58437636 @default.
• W2511831439 hasConcept C97355855 @default.
• W2511831439 hasConceptScore W2511831439C113196181 @default.
• W2511831439 hasConceptScore W2511831439C11432220 @default.
• W2511831439 hasConceptScore W2511831439C119947313 @default.
• W2511831439 hasConceptScore W2511831439C121332964 @default.
• W2511831439 hasConceptScore W2511831439C127413603 @default.
• W2511831439 hasConceptScore W2511831439C140820882 @default.
• W2511831439 hasConceptScore W2511831439C147789679 @default.
• W2511831439 hasConceptScore W2511831439C15744967 @default.
• W2511831439 hasConceptScore W2511831439C184651966 @default.
• W2511831439 hasConceptScore W2511831439C185592680 @default.
• W2511831439 hasConceptScore W2511831439C188027245 @default.
• W2511831439 hasConceptScore W2511831439C192562407 @default.
• W2511831439 hasConceptScore W2511831439C2779587474 @default.
• W2511831439 hasConceptScore W2511831439C42360764 @default.
• W2511831439 hasConceptScore W2511831439C43617362 @default.
• W2511831439 hasConceptScore W2511831439C542102704 @default.
• W2511831439 hasConceptScore W2511831439C58437636 @default.
• W2511831439 hasConceptScore W2511831439C97355855 @default.
• W2511831439 hasFunder F4320320879 @default.
• W2511831439 hasLocation W25118314391 @default.
• W2511831439 hasLocation W25118314392 @default.
• W2511831439 hasOpenAccess W2511831439 @default.
• W2511831439 hasPrimaryLocation W25118314391 @default.
• W2511831439 hasRelatedWork W1987827016 @default.
• W2511831439 hasRelatedWork W2034478052 @default.
• W2511831439 hasRelatedWork W2054897892 @default.
• W2511831439 hasRelatedWork W2125525143 @default.
• W2511831439 hasRelatedWork W2247114993 @default.
• W2511831439 hasRelatedWork W2253744755 @default.

• next