FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511851700> ?p ?o ?g. }

• W2511851700 endingPage "212" @default.
• W2511851700 startingPage "205" @default.
• W2511851700 abstract "Monocytes from patients with systemic juvenile idiopathic arthritis (SJIA) have both features of classical activated M1 and alternatively activated M2 macrophages. An increasing number of studies have indicated that microRNAs (miRNAs) are critical regulators of monocyte polarization. Here, we focused on miR-146a expression in SJIA and investigated the function of miR-146a in monocyte polarization. We found that miR-146a expression was highly up-regulated in SJIA monocytes and correlated with the systemic features. miR-146a was expressed at a higher level in monocytes polarized with M2 conditions than those polarized with M1 conditions. miR-146a overexpression significantly decreased the production of M1 phenotype markers such as IL-6, IL-12, TNF-α, CD86 and iNOS in M1 macrophages, but increased the production of M2 marker genes such as Arg1, CCL17, CCL22 and CD206 in M2 macrophages. Conversely, knockdown of miR-146a promoted M1 macrophage polarization but diminished M2 macrophage polarization. We subsequently demonstrated that miR-146a targeted the 3'-untranslated region (UTR) of INHBA to inhibit its expression. Additionally, INHBA overexpression rescued the reduced IL-6, IL-12, and TNF-α levels induced by miR-146a overexpression in M1 macrophages, and rescued the increased Arg1, CCL17, and CCL22 levels induced by miR-146a overexpression in M2 macrophages. Similarly, the effects of miR-146a inhibition in monocyte polarization were all partly reversed by INHBA inhibition. Taken together, the data suggest that miR-146a serves as a molecular regulator in monocyte polarization and might play an important role in monocytes from patients with SJIA." @default.
• W2511851700 created "2016-09-16" @default.
• W2511851700 creator A5006799132 @default.
• W2511851700 creator A5012378388 @default.
• W2511851700 creator A5016890292 @default.
• W2511851700 creator A5038851564 @default.
• W2511851700 creator A5066726271 @default.
• W2511851700 creator A5086861827 @default.
• W2511851700 date "2016-09-01" @default.
• W2511851700 modified "2023-10-16" @default.
• W2511851700 title "MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA" @default.
• W2511851700 cites W1975043165 @default.
• W2511851700 cites W1976556343 @default.
• W2511851700 cites W1978330061 @default.
• W2511851700 cites W1979206745 @default.
• W2511851700 cites W1982871919 @default.
• W2511851700 cites W1984472246 @default.
• W2511851700 cites W2010387075 @default.
• W2511851700 cites W2015284016 @default.
• W2511851700 cites W2022305566 @default.
• W2511851700 cites W2038180405 @default.
• W2511851700 cites W2039794526 @default.
• W2511851700 cites W2042207589 @default.
• W2511851700 cites W2051611327 @default.
• W2511851700 cites W2062811480 @default.
• W2511851700 cites W2070086022 @default.
• W2511851700 cites W2075860675 @default.
• W2511851700 cites W2077124851 @default.
• W2511851700 cites W2081810806 @default.
• W2511851700 cites W2096905901 @default.
• W2511851700 cites W2098966232 @default.
• W2511851700 cites W2099808663 @default.
• W2511851700 cites W2110995918 @default.
• W2511851700 cites W2114155762 @default.
• W2511851700 cites W2125372614 @default.
• W2511851700 cites W2127669794 @default.
• W2511851700 cites W2129898094 @default.
• W2511851700 cites W2135483888 @default.
• W2511851700 cites W2156584537 @default.
• W2511851700 cites W2162762911 @default.
• W2511851700 cites W2172089049 @default.
• W2511851700 cites W2183032103 @default.
• W2511851700 cites W2215729635 @default.
• W2511851700 cites W2240089400 @default.
• W2511851700 cites W2279015277 @default.
• W2511851700 doi "https://doi.org/10.1016/j.molimm.2016.08.007" @default.
• W2511851700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27541693" @default.
• W2511851700 hasPublicationYear "2016" @default.
• W2511851700 type Work @default.
• W2511851700 sameAs 2511851700 @default.
• W2511851700 citedByCount "53" @default.
• W2511851700 countsByYear W25118517002017 @default.
• W2511851700 countsByYear W25118517002018 @default.
• W2511851700 countsByYear W25118517002019 @default.
• W2511851700 countsByYear W25118517002020 @default.
• W2511851700 countsByYear W25118517002021 @default.
• W2511851700 countsByYear W25118517002022 @default.
• W2511851700 countsByYear W25118517002023 @default.
• W2511851700 crossrefType "journal-article" @default.
• W2511851700 hasAuthorship W2511851700A5006799132 @default.
• W2511851700 hasAuthorship W2511851700A5012378388 @default.
• W2511851700 hasAuthorship W2511851700A5016890292 @default.
• W2511851700 hasAuthorship W2511851700A5038851564 @default.
• W2511851700 hasAuthorship W2511851700A5066726271 @default.
• W2511851700 hasAuthorship W2511851700A5086861827 @default.
• W2511851700 hasConcept C104317684 @default.
• W2511851700 hasConcept C127561419 @default.
• W2511851700 hasConcept C13373296 @default.
• W2511851700 hasConcept C134678942 @default.
• W2511851700 hasConcept C143172330 @default.
• W2511851700 hasConcept C145059251 @default.
• W2511851700 hasConcept C173396325 @default.
• W2511851700 hasConcept C185592680 @default.
• W2511851700 hasConcept C202751555 @default.
• W2511851700 hasConcept C203014093 @default.
• W2511851700 hasConcept C2776090121 @default.
• W2511851700 hasConcept C2776682551 @default.
• W2511851700 hasConcept C2776914184 @default.
• W2511851700 hasConcept C2777077863 @default.
• W2511851700 hasConcept C2779244956 @default.
• W2511851700 hasConcept C2781101188 @default.
• W2511851700 hasConcept C2781184567 @default.
• W2511851700 hasConcept C2910375186 @default.
• W2511851700 hasConcept C502942594 @default.
• W2511851700 hasConcept C54355233 @default.
• W2511851700 hasConcept C5858377 @default.
• W2511851700 hasConcept C81885089 @default.
• W2511851700 hasConcept C86803240 @default.
• W2511851700 hasConcept C8891405 @default.
• W2511851700 hasConcept C95444343 @default.
• W2511851700 hasConceptScore W2511851700C104317684 @default.
• W2511851700 hasConceptScore W2511851700C127561419 @default.
• W2511851700 hasConceptScore W2511851700C13373296 @default.
• W2511851700 hasConceptScore W2511851700C134678942 @default.
• W2511851700 hasConceptScore W2511851700C143172330 @default.
• W2511851700 hasConceptScore W2511851700C145059251 @default.
• W2511851700 hasConceptScore W2511851700C173396325 @default.
• W2511851700 hasConceptScore W2511851700C185592680 @default.

• next