FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2511856532> ?p ?o ?g. }

• W2511856532 endingPage "1285" @default.
• W2511856532 startingPage "1285" @default.
• W2511856532 abstract "<h3>Importance</h3> Calcium is a key cofactor of the coagulation cascade and may play a role in the pathophysiology of intracerebral hemorrhage (ICH). <h3>Objective</h3> To investigate whether a low serum calcium level is associated with an increase in the extent of bleeding in patients with ICH as measured by baseline hematoma volume and risk of hematoma expansion. <h3>Design, Setting, and Participants</h3> Prospective cohort study of 2103 consecutive patients with primary ICH ascertained during the period between 1994 and 2015 at an academic medical center. The statistical analysis was performed in January 2016. <h3>Main Outcomes and Measures</h3> Total calcium level was measured on admission, and hypocalcemia was defined as a serum calcium level of less than 8.4 mg/dL. Baseline and follow-up hematoma volumes, detected by noncontrast computed tomography, were measured using a computer-assisted semiautomatic analysis. Hematoma expansion was defined as an increase of more than 30% or 6 mL from baseline ICH volume. Associations between serum calcium level and baseline hematoma volume and between serum calcium level and ICH expansion were investigated in multivariable linear and logistic regression models, respectively. <h3>Results</h3> A total of 2123 patients with primary ICH were screened, and 2103 patients met the inclusion criteria (mean [SD] age, 72.7 [12.5] years; 54.3% male patients), of whom 229 (10.9%) had hypocalcemia on admission. Hypocalcemic patients had a higher median baseline hematoma volume than did normocalcemic patients (37 mL [IQR, 15-72 mL] vs 16 mL [IQR, 6-44 mL];<i>P</i> < .001). Low calcium levels were independently associated with higher baseline ICH volume (β = −0.13, SE = .03,<i>P</i> < .001). A total of 1393 patients underwent follow-up noncontrast computed tomography and were included in the ICH expansion analysis. In this subgroup, a higher serum calcium level was associated with reduced risk of ICH expansion (odds ratio, 0.55 [95% CI, 0.35-0.86];<i>P</i> = .01), after adjusting for other confounders. <h3>Conclusions and Relevance</h3> Hypocalcemia correlates with the extent of bleeding in patients with ICH. A low calcium level may be associated with a subtle coagulopathy predisposing to increased bleeding and might therefore be a promising therapeutic target for acute ICH treatment trials." @default.
• W2511856532 created "2016-09-16" @default.
• W2511856532 creator A5001829677 @default.
• W2511856532 creator A5006140547 @default.
• W2511856532 creator A5006664647 @default.
• W2511856532 creator A5010639373 @default.
• W2511856532 creator A5026473307 @default.
• W2511856532 creator A5034035251 @default.
• W2511856532 creator A5045316816 @default.
• W2511856532 creator A5045439266 @default.
• W2511856532 creator A5055117066 @default.
• W2511856532 creator A5056733365 @default.
• W2511856532 creator A5061174828 @default.
• W2511856532 creator A5062339766 @default.
• W2511856532 creator A5063509357 @default.
• W2511856532 date "2016-11-01" @default.
• W2511856532 modified "2023-10-18" @default.
• W2511856532 title "Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage" @default.
• W2511856532 cites W1947113872 @default.
• W2511856532 cites W1963627517 @default.
• W2511856532 cites W1965021019 @default.
• W2511856532 cites W1966921182 @default.
• W2511856532 cites W1968517907 @default.
• W2511856532 cites W1971096671 @default.
• W2511856532 cites W1975718315 @default.
• W2511856532 cites W1981194197 @default.
• W2511856532 cites W2000616430 @default.
• W2511856532 cites W2007301755 @default.
• W2511856532 cites W2012129780 @default.
• W2511856532 cites W2024337557 @default.
• W2511856532 cites W2033577946 @default.
• W2511856532 cites W2038287016 @default.
• W2511856532 cites W2041063076 @default.
• W2511856532 cites W2075849746 @default.
• W2511856532 cites W2091867574 @default.
• W2511856532 cites W2092496546 @default.
• W2511856532 cites W2092667233 @default.
• W2511856532 cites W2094234835 @default.
• W2511856532 cites W2105662874 @default.
• W2511856532 cites W2107281754 @default.
• W2511856532 cites W2108897505 @default.
• W2511856532 cites W2119853075 @default.
• W2511856532 cites W2182525210 @default.
• W2511856532 cites W3171831654 @default.
• W2511856532 cites W4210987237 @default.
• W2511856532 doi "https://doi.org/10.1001/jamaneurol.2016.2252" @default.
• W2511856532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5287716" @default.
• W2511856532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27598746" @default.
• W2511856532 hasPublicationYear "2016" @default.
• W2511856532 type Work @default.
• W2511856532 sameAs 2511856532 @default.
• W2511856532 citedByCount "71" @default.
• W2511856532 countsByYear W25118565322016 @default.
• W2511856532 countsByYear W25118565322017 @default.
• W2511856532 countsByYear W25118565322018 @default.
• W2511856532 countsByYear W25118565322019 @default.
• W2511856532 countsByYear W25118565322020 @default.
• W2511856532 countsByYear W25118565322021 @default.
• W2511856532 countsByYear W25118565322022 @default.
• W2511856532 countsByYear W25118565322023 @default.
• W2511856532 crossrefType "journal-article" @default.
• W2511856532 hasAuthorship W2511856532A5001829677 @default.
• W2511856532 hasAuthorship W2511856532A5006140547 @default.
• W2511856532 hasAuthorship W2511856532A5006664647 @default.
• W2511856532 hasAuthorship W2511856532A5010639373 @default.
• W2511856532 hasAuthorship W2511856532A5026473307 @default.
• W2511856532 hasAuthorship W2511856532A5034035251 @default.
• W2511856532 hasAuthorship W2511856532A5045316816 @default.
• W2511856532 hasAuthorship W2511856532A5045439266 @default.
• W2511856532 hasAuthorship W2511856532A5055117066 @default.
• W2511856532 hasAuthorship W2511856532A5056733365 @default.
• W2511856532 hasAuthorship W2511856532A5061174828 @default.
• W2511856532 hasAuthorship W2511856532A5062339766 @default.
• W2511856532 hasAuthorship W2511856532A5063509357 @default.
• W2511856532 hasBestOaLocation W25118565321 @default.
• W2511856532 hasConcept C126322002 @default.
• W2511856532 hasConcept C141071460 @default.
• W2511856532 hasConcept C151956035 @default.
• W2511856532 hasConcept C164705383 @default.
• W2511856532 hasConcept C17624336 @default.
• W2511856532 hasConcept C188816634 @default.
• W2511856532 hasConcept C2777094939 @default.
• W2511856532 hasConcept C2779662492 @default.
• W2511856532 hasConcept C42219234 @default.
• W2511856532 hasConcept C519063684 @default.
• W2511856532 hasConcept C71924100 @default.
• W2511856532 hasConceptScore W2511856532C126322002 @default.
• W2511856532 hasConceptScore W2511856532C141071460 @default.
• W2511856532 hasConceptScore W2511856532C151956035 @default.
• W2511856532 hasConceptScore W2511856532C164705383 @default.
• W2511856532 hasConceptScore W2511856532C17624336 @default.
• W2511856532 hasConceptScore W2511856532C188816634 @default.
• W2511856532 hasConceptScore W2511856532C2777094939 @default.
• W2511856532 hasConceptScore W2511856532C2779662492 @default.
• W2511856532 hasConceptScore W2511856532C42219234 @default.
• W2511856532 hasConceptScore W2511856532C519063684 @default.
• W2511856532 hasConceptScore W2511856532C71924100 @default.
• W2511856532 hasIssue "11" @default.

• next