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- W2511882623 abstract "n engl j med 374;22 nejm.org June 2, 2016 2195 only one cerebellar hemisphere in 3 infants. In 2 infants, the brain stem was globally hypoplastic. In all the infants, there was abnormal hypodensity of the white matter, and in 87% of the patients it diffusely involved all the cerebral lobes. In 1 infant, chronic encephalomalacic changes from ischemic stroke in the vascular territory of the left middle cerebral artery were seen. Intrauterine ZIKV infection appears to be associated with severe brain anomalies, including calcifications, cortical hypogyration, ventriculomegaly, and white-matter abnormalities, although we cannot determine with certainty when ZIKV infection may have occurred during fetal development in these 23 infants. Our findings are nonspecific and may be seen in other congenital viral infections. The global presence of cortical hypogyration and white-matter hypomyelination or dysmyelination in all the infants and cerebellar hypoplasia in the majority of them suggest that ZIKV is associated with a disruption in brain development rather than destruction of brain. The neuronal and glial proliferation as well as neuronal migration appear to be affected. The mothers of the microcephalic infants in our study population had symptoms (e.g., low-grade fever and cutaneous rash) that were compatible with ZIKV infection during the first or second trimester of pregnancy, similar to the findings in other studies.4 Tang et al. found that ZIKV directly infects human cortical neural progenitor cells with high efficiency, resulting in stunted growth of this cell population and transcriptional dysregulation.5 This observation supports the type of disruptive, anomalous brain development that we found in these infants. Adriano N. Hazin, M.D." @default.
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- W2511882623 date "2016-01-01" @default.
- W2511882623 modified "2023-09-27" @default.
- W2511882623 title "Evidence of Sexual Transmission of Zika Virus" @default.
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